Application of lateral counting corrections when measuring cerebral blood flow

Wyper, David J.; Cooke, Miriam

doi:10.1088/0031-9155/23/6/009

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…On the other hand, �25% of the signal received by a stationary detector placed over one hemisphere will originate from the contralateral hemisphere (Blauenstein et aI. , 1977;Wyper and Cooke, 1978;Bolmsjo, 1984). Thus, the interhemispheric asym metry will be smoothed and, according to Bolmsjo (1984), detected as only 50% of its true value.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Xenon-133 Measurements of Cerebral Blood Flow Using Stationary Detectors Compared with Dynamic Emission Tomography

Schroeder

Vorstrup

Lassen

et al. 1986

J Cereb Blood Flow Metab

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Repeated bedside measurements of CBF have been made possible by the recent development of a mobile unit with 10 stationary detectors using the intravenous xenon-133 method. To evaluate this technique, comparative CBF studies at rest and following the application of a cerebral vasodilatory stimulus (acetazolamide, 1 g i.v.) were performed with the mobile equipment and with xenon-133 single-photon emission inhalation tomography in patients with cerebrovascular disease. The CBF level and the flow response to acetazolamide as determined with the two methods were well correlated, although at low flow levels the stationary detectors yielded somewhat lower CBF values than did emission tomography. Considering the side-to-side asymmetry, an excellent correlation was obtained. Using the initial slope index, the stationary detectors revealed quantitatively 83% of the interhemispheric asymmetry and 63% of the asymmetry in the middle cerebral artery territory shown with the tomograph. As illustrated by a case history, the nontomographic CBF unit used in this study may provide reliable and useful information in patients with occlusive cerebrovascular disease by performing repeated CBF studies and challenging the cerebral circulation with acetazolamide.

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Section: Discussionmentioning

confidence: 99%