Application of large-scale hollow fiber membrane contactors for simultaneous extractive removal and stripping of penicillin G

Mass transfer in liquid–liquid membrane-based extraction at small fiber packing fractions

“…The membrane resistance in the data of Table 5 To compute the mass transfer coefficients k w and k o , Eqs. (8) and (19) are employed, respectively. The great influence Table 5 Estimated partial and overall mass transfer coefficients and the respective percentage contribution to total resistance, for the Re o and Re w ranges tested, for the system water-benzaldehyde-n-hexane …”

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

“…Supported liquid membranes (SLM) on the other hand, which typically contain a lipid solution of an organic solvent immobilised on a polymer membrane, are very stable and have intrinsic durability and are therefore suitable for use in the industrial setting and even large scale applications. SLMs were successfully applied in transfer studies of drug molecules, namely in prediction of drug absorption in humans using the artificial membrane permeability method Parallel Artificial Membrane Permeation Assay (PAMPA) [35][36][37], cellmonolayer permeability assays such as human epithelial colorectal adenocarcinoma (Caco-2) [38][39][40] or Madin-Darby canine kidney (MDCK) [41], drug lipophilicity determination [37,42,43] and extraction/removal of drugs [44,45].…”

Recent advances in supported liquid membrane technology

“…Extraction of Penicillin G was carried out using two hollow fiber modules with organic phase containing a secondary amine Amberlite LA-2 as a carrier, 10% isodecanol as a modifier and kerosene as a diluent. The effects of initial feed concentration and carrier concentration on the kinetics of the complex mass transfer process were examined [87].…”