Application of Laboratory Controls in Clinical Chemistry

In Which Areas of Clinical Chemistry and Haematologic Laboratory Diagnostics Could the Use of Reagents Stemming from Human Plasma be Reduced? To Which Extent Could Such Reagents be Replaced by Artificial Substrates or Reagents Based upon Animal Plasma?

“…Benenson and coworkers noted that pooled human serum was satisfactory for quality control of most routine analyses, but they re commended that animal serums that were collect ed with sterile technique and quickly frozen at -10 °C were preferable for enzymatic analyses, such as acid and alkaline phosphatase, amylase and lipase. Benenson et al [1] observed that rabbit serum was particularly suitable for this purpose, since the amylase activity of pooled rab bit serum approximated the values that were ob tained in serum specimens from healthy human subjects.…”

“…In 1955, Benenson et al [1] published a pioneering study on the use of quality control serums in order to monitor the day-to-day precision of anal yses that are performed in clinical chemistry laboratories. Benenson and coworkers noted that pooled human serum was satisfactory for quality control of most routine analyses, but they re commended that animal serums that were collect ed with sterile technique and quickly frozen at -10 °C were preferable for enzymatic analyses, such as acid and alkaline phosphatase, amylase and lipase.…”