Application of iron oxide nanoparticles in the diagnosis and treatment of leukemia

Abstract

Leukemia is a malignancy initiated by uncontrolled proliferation of hematopoietic stem cell from the B and T lineages, resulting in destruction of hematopoietic system. The conventional leukemia treatments induce severe toxic and a long series of unwanted side-effects which are caused by lack of specificity of anti-leukemic drugs. Recently, nanotechnology have shown tremendous application and clinical impact with respect to diagnosis and treatment of leukemia. According to considerable researches in the context of finding new nanotechnological platform, iron oxide nanoparticles have been gained increasing attention for the leukemia patients use. In this review, a short introduction of leukemia is described followed by the evaluation of the current approaches of iron oxide nanoparticles applied in the leukemia detection and treatment. The enormous advantages of iron oxide nanoparticles for leukemia have been discussed, which consist of the detection of magnetic resonance imaging (MRI) as efficient contrast agents, magnetic biosensors and targeted delivery of anti-leukemia drugs by coating different targeting moieties. In addition, this paper will briefly describe the application of iron oxide nanoparticles in the combined treatment of leukemia. Finally, the shortcomings of the current applications of iron-based nanoparticles in leukemia diagnosis and treatment will be discussed in particular.

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

“…In addition, SPION can be used for drug delivery and magnetic thermotherapy. In drug delivery, drugs can be encapsulated in NPs and delivered precisely to the lesion site by magnetic field induction, thereby improving drug efficacy and reducing side effects 147–149 . As for magnetic hyperthermia, the heat generated by NPs in an alternating magnetic field (AMF) can be used to kill tumor cells, thus achieving the goal of treating tumors 150–152 .…”

“…In drug delivery, drugs can be encapsulated in NPs and delivered precisely to the lesion site by magnetic field induction, thereby improving drug efficacy and reducing side effects. 147 , 148 , 149 As for magnetic hyperthermia, the heat generated by NPs in an alternating magnetic field (AMF) can be used to kill tumor cells, thus achieving the goal of treating tumors. 150 , 151 , 152 In conclusion, SPION is a promising nanomaterial with a wide range of applications, and research on its preparation and application is constantly deepening and developing.…”

Chemotherapeutic Potential of AgNP Orchestrated Semecarpus anacardium Nut Extracts Against Ovarian Cancer Cell Line, PA-1

“…The difficulties posed by using harmful chemical reagents may be resolved by the synthesis of AgNPs using phyto molecules. Other than silver, several metal nanoparticles have been used for synthesizing nanoparticles which are used in different cancers to prove their efficacy in chemotherapeutics as well as immunotherapy [51][52][53][54][55][56][57][58][59][60][61][65][66][67][68][69][70]. Apart from metal nanoparticles, synthesis of photonic nanoparticles has also been tremendously increased in the recent years for cancer therapeutics [62].…”

Magnetic Nanoparticles: Synthesis, Characterization, and Their Use in Biomedical Field

“…For example, iron oxide nanoparticles conjugated with various antibodies were used to image glioma [161,162], glioblastoma [163], breast [164], pancreatic [165], colorectal [166], prostate [167], and other cancers [168].…”