Application of Ipomoea batatas starch as suspending agent in acetaminophen suspension

Ikechukwu, Vitus; A, Chime Salome; Ifeoma, Kanu

doi:10.5897/ajpp12.1310

Cited by 2 publications

(2 citation statements)

References 11 publications

(9 reference statements)

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“…The non-conventional sources have been exploited for development of starch with wide applicability in pharmaceutical formulations as tablet binders and disintegrants, glidants, suspending and emulsifying agents. [1][2][3][4][5][6] Although starch in its native form has many potentials, its poor flow properties, instability when exposed to high temperature and under high shear rate, variations in pH, high retrogradation, its limited solubility in common organic solvents and freeze-thaw processes make them less desirable for industrial applications. [7][8][9] The goal of many formulation scientists therefore, is to find means of overcoming these limitations while developing versatile starch-based excipients that have multifunctional applications.…”

Section: Introductionmentioning

confidence: 99%

Green preparation of citric acid cross-linked starch for improvement of physico-chemical properties of Cyperus starch

Olayemi¹,

Isimi²,

Ekere³

et al. 2019

tjps

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INTRODUCTION: This study was undertaken to assess the properties of Cyperus esculentus tuber starch cross-linked with citric acid from liquid substrates of orange peel derived via the natural solid-state fermentation process; a green-approach. METHODS: The flow properties of the prepared starches were evaluated using standard methods. Water holding capacity, swelling capacity, moisture sorption capacity, gelatinization temperature using Differential Scanning Calorimetry (DSC), morphology, Fourier Infrared Spectroscopy and pH of the starches were evaluated. RESULTS: According to the results the pH of the cross-linked starches were lower (3.39-4.07) than that of the native starch (5.25) and flow profile was found to improve. Water holding capacity (90.67-96.69 %) of the cross-linked starches were higher while emulsion capacity (15.33) was similar to that of the native starch (15.33). No change was observed in the morphology of the granules of the cross-linked starches. The infrared spectra of the native and cross-linked starches showed identical peaks; the enthalpy of gelatinization (ΔHgel) of the crosslinked products were found to differ from that of the native starch. The modified starches show propensity of being exploited as binding agents in food and pharmaceutical industries. DISCUSSION AND CONCLUSION: The green process of modification has proved to be value addition to the processes of starch modification available.

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Section: Introductionmentioning

confidence: 99%

Green preparation of citric acid cross-linked starch for improvement of physico-chemical properties of Cyperus starch

Olayemi¹,

Isimi²,

Ekere³

et al. 2019

tjps

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“…The sources of suspending agents can be natural (mucilage), synthetic (polyvinyl pyrrolidone), or semisynthetic (cellulose derivatives) polymers [ 7 ]. However; the use of natural polymers like mucilages for pharmaceutical applications as a suspending agent is fascinating because they are cheap, effortlessly available, nontoxic, amenable to chemical modifications, and potentially biocompatible [ 8 ]. Moreover, natural polymers have a wide range of applications in different fields like locust bean gum-based hydrogels that are reported to be utilized as an alternative and promising adsorbent for the treatment of effluents containing water-soluble cationic dye-brilliant green [ 9 ], sodium alginate stabilized silver nanoparticle-silica nanohybrid that has various antibacterial applications in biotechnology and biomedical fields [ 10 ], and κ -carrageenan-based silver nanoparticle nanocatalysts that exhibit high catalytic degradation and mineralization of industrially important organic dyes such as rhodamine B and methylene blue, with a degradation efficiency of 100% in a very short period of time [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Aloe elegans Mucilage as a Suspending Agent in Paracetamol Suspension

Woldu

Baymot

Tesfay

et al. 2021

BioMed Research International

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Background. There are various natural excipients which have been used as suspending agents in pharmaceutical suspensions due to the presence of mucilage in their specialized cells and their capacity to form a colloidal gel in an aqueous medium. Objective. The purpose of this study was to evaluate the suspending capacity of Aloe elegans mucilage in suspension formulations. Materials and Methods. Aloe elegans mucilage (AEM) was evaluated as a suspending agent in comparison with xanthan gum (XG) in paracetamol suspensions at 1, 2, 3, 4, and 5% ( w / v ) concentrations. The resulting suspensions were evaluated for their sedimentation volume, apparent viscosity, flow rate, rate of redispersibility, pH, assay, and dissolution profile. Results. The volume of sedimentation, apparent viscosity, and redispersibility rate of the formulations were significantly increased ( p < 0.05 ), with the concentration of the suspending agents. Meanwhile, the apparent viscosity for all formulations has significantly decreased ( p < 0.05 ) with an increase in shear rates. Volume of sedimentation, apparent viscosity, and redispersibility degree of the formulations prepared with AEM were significantly ( p < 0.05 ) lower than XG-containing formulations at the same concentration. Nevertheless, the sedimentation volume of all formulations with AEM was significantly ( p < 0.05 ) higher than the suspension without any suspending agent. With regard to drug content and pH values, all formulations showed an acceptable result with the standards. All formulations showed a release of greater than 85% of drug content within 45 min. Conclusion. Aloe elegans mucilage could have a potential to be utilized as an alternative suspending agent in pharmaceutical suspensions.

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Application of Ipomoea batatas starch as suspending agent in acetaminophen suspension

Cited by 2 publications

References 11 publications

Green preparation of citric acid cross-linked starch for improvement of physico-chemical properties of Cyperus starch

Green preparation of citric acid cross-linked starch for improvement of physico-chemical properties of Cyperus starch

Evaluation of Aloe elegans Mucilage as a Suspending Agent in Paracetamol Suspension

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