Application of Ion‐Doped Y₃Fe₅O₁₂ Nanoparticles for Self‐Controlled Magnetic Hyperthermia

Abstract

Herein, doped yttrium garnet (YIG) nanoparticles (NPs) normalY 3 false[ F normale 2 − y M y false] a false( F normale 3 − z M z false) d normalO 12 ( M = Al, Ga, Sc are nonmagnetic ions) are studied, appropriate for self‐controlled magnetic hyperthermia (SCMH) for in vivo and in vitro applications. A microscopic model (modified Heisenberg Hamiltonian) and the Green's function technique are used to investigate the temperature, doping, and size dependence of magnetic phase transition, saturation magnetization, the coercivity, and the specific absorption rate coefficient to fulfill the conditions for magnetic hyperthermia. A set of mixed yttrium garnet magnetic NPs is found, which are suitable for applications in medicine for cancer therapy. There are two Sc‐doped YIG NPs which are the best candidates for SCMH with x = 1.08, d = 27.5 nm, and SAR max = 13.52 W normalg − 1 , as well as x = 1.10, d = 29.7 nm, and SAR max = 15.44 W normalg − 1 for which the conditions for biocompatibility and maximization of SAR are fulfilled simultaneously. Moreover, also Al‐ and Ga‐doped YIG NPs are found that can be applied for magnetic hyperthermia but with smaller SAR effectivity.

Size-Dependent Structural, Magnetic and Magnetothermal Properties of Y3Fe5O12 Fine Particles Obtained by SCS

“…Despite tremendous works related to searching for advanced compounds with better performance of magnetothermal properties for promising application in magnetothermic or ablation of pathogenic cells, there are only a few papers that deal with the study of Y 3 Fe 5 O 12 -based particles [10,12,34]. The high heat generation ability of submicron YIG particles was demonstrated, but the data related to bacterial activity and toxicity of this compound seems controversial.…”