Application of indocyanine green in pediatric surgery

Lau, Chak‐Sing; Au, Danise M.; Wong, Kenneth K.

doi:10.1007/s00383-019-04502-4

Cited by 44 publications

(35 citation statements)

References 53 publications

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“…Since then, its applications have been expanded to include fluorescent imaging, retinal angiography, vitreoretinal surgery, assessment of liver function, surgical oncology, assessment of burn wound severity, and clinical imaging of the lymphatic system. [4][5][6][7] Its use has expanded to include the pediatric population; however, to date, reports have been largely anecdotal regarding both its use and its adverse effect profile. Some of the recent reports have demonstrated its successful application in the pediatric population (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…ICG is the only clinically approved dye for NIR fluorescence imaging. [5][6][7]18 ICG has been shown be a relatively safe dye with a low incidence of adverse effects. It is not metabolized after injection and is almost exclusively excreted by the liver into bile.…”

Section: Discussionmentioning

confidence: 99%

“…ICG has been used clinically since 1956 for angiography, to measure cardiac output or cerebral blood flow, evaluate hepatic function, and assess regional blood flow assessment. [4][5][6][7] After intravenous administration, the dye is bound by plasma proteins, remaining intravascular, thereby allowing blood vessels to be visualized when the tissue is illuminated and observed at appropriate wavelengths of light. In recent studies, its clinical application has been tested in the treatment of cancer, laparoscopic procedures, and reconstructive colorectal and vascular surgeries.…”

Section: Introductionmentioning

confidence: 99%

“…In recent studies, its clinical application has been tested in the treatment of cancer, laparoscopic procedures, and reconstructive colorectal and vascular surgeries. 6,7 Currently, there are limited data available regarding its use, dosing, and adverse effect profile in the pediatric population. We retrospectively reviewed our experience with the intraoperative use of ICG in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Shafy¹,

Hakim²,

Lynch³

et al. 2020

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVES Fluorescence imaging using indocyanine green (ICG) allows for the intraoperative mapping of the vascular supply of various tissue beds. Although generally safe and effective, rare adverse effects have been reported including anaphylactoid reactions. The current study retrospectively reviewed our experience the intraoperative administration of ICG to pediatric patients. METHODS The anesthetic records of patients who received ICG over a 2-year time period were retrospectively reviewed and demographic, surgical, and medication data retrieved. Objective intraoperative data before and after the administration of ICG were also recorded. These included heart rate, systolic and diastolic blood pressures, oxygen saturation, and peak inflating pressure. RESULTS The study cohort included 100 patients with a median age of 12 years (9.5 ± 7.4 years) and the median weight being 44.5 kg (45.9 ± 36.9 kg). ICG was administered intravenously to all patients. In all cases, 2.5 mg/mL ICG solution was used, with a median dose of 1.1 mL (1.79 ± 1.8 mL). Eight patients received more than 1 dose of ICG, with no adverse respiratory or hemodynamic effects related to its use. CONCLUSIONS ICG fluorescence is an important imaging modality that can be safely used as an intraoperative adjunct to various surgical procedures in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Shafy¹,

Hakim²,

Lynch³

et al. 2020

The Journal of Pediatric Pharmacology and Therapeutics

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“…ICG is a fluorescent iodide dye traditionally used to assess hepatic and cardiac function (Lau, Au, & Wong, 2019). Excited by near-infrared light, ICG emits fluorescence that is captured by a special camera.…”

Section: Discussionmentioning

confidence: 99%

Robotic‐assisted laparoscopic artery‐sparing varicocelectomy using indocyanine green fluorescence angiography: Initial experience

Teng

Jia

et al. 2020

Andrologia

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We reported our initial experience of robotic‐assisted laparoscopic artery‐sparing varicocelectomy using indocyanine green (ICG) fluorescence angiography in treatment of varicocele. A total of 45 varicocelectomies in 27 patients were performed. The mean operation time was 49.1 ± 8.5 min for unilateral and 65.6 ± 8.3 min for bilateral repair. 47.2 s after ICG injection, testicular artery (TA) was visualised. After an interval of 31.3 s, fluorescent veins were identified. Of all the 45 spermatic cords, 68.9% had a solitary artery, while 31.1% had 2 arteries. The mean hospital stay was 1.6 ± 0.9 days. Semen concentration and motility were significantly improved 6 months after surgery, no recurrence, hydrocele or testicular atrophy was observed. Our study demonstrated that robotic‐assisted laparoscopic artery‐sparing varicocelectomy using ICG fluorescence angiography is a safe, effective and promising technique in treatment of varicocele.

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Newer Technologies

Patel

Pachl

2023

Pediatric Surgical Oncology

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Application of indocyanine green in pediatric surgery

Cited by 44 publications

References 53 publications

Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Robotic‐assisted laparoscopic artery‐sparing varicocelectomy using indocyanine green fluorescence angiography: Initial experience

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