Application of hypoglossal nerve constraint in definitive radiotherapy for nasopharyngeal carcinoma: A dosimetric feasibility study

Chow, J.C.H.; Lui, Jeffrey C.F.; Au, Kwok‐Hung; Cheung, Ka Man; Ngan, Roger K.C.; Leung, Alexander Moon Ho; Li, Kenneth W.S.; Chan, Jeffrey; Wong, Kevin; Lee, Francis K.H.

doi:10.1016/j.meddos.2020.07.002

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Cited by 3 publications

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“…Hypoglossal nerve D1cc ≥ 74 Gy was associated with a high risk of future palsy (8-year; D1cc ≥ 74 Gy, 20.8%; D1cc < 74 Gy, 2.4%). By applying a dedicated dose constraint to remove hotspots within the hypoglossal nerves, neither the tumor target coverage nor dosimetric safety of other standard critical organs was compromised [ 60 ]. Its application should be routinely considered for NPC radiotherapy planning especially when dose escalation to the primary nasopharyngeal tumor is contemplated.…”

Section: Sparing Organs At Riskmentioning

confidence: 99%

Current Radiotherapy Considerations for Nasopharyngeal Carcinoma

Chow

Beitler³

et al. 2022

Cancers

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Radiotherapy is the primary treatment modality for nasopharyngeal carcinoma (NPC). Successful curative treatment requires optimal radiotherapy planning and precise beam delivery that maximizes locoregional control while minimizing treatment-related side effects. In this article, we highlight considerations in target delineation, radiation dose, and the adoption of technological advances with the aim of optimizing the benefits of radiotherapy in NPC patients.

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Section: Sparing Organs At Riskmentioning

confidence: 99%