Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole

Démuth, Balázs; Galata, Dorián László; Balogh, Attila; Szabó, Edina; Nagy, Brigitta; Farkas, Attila; Hirsch, Edit; Pataki, Hajnalka; Vígh, Tamás; Mensch, J.; Verreck, Geert; Nagy, Zsombor Kristóf; Marosi, Gyoergy

doi:10.1016/j.ejps.2018.06.008

Cited by 13 publications

(5 citation statements)

References 33 publications

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“…HPMC-AS has recently been widely used to stabilize APIs in ASDs. ,,,, This is due to its unique physical–chemical properties such as a high glass transition temperature (around 120 °C) and the presence of both acetyl (A) and succinoyl (S) moieties (Figure ), which allow for the effective inhibition of drug crystallization from the amorphous dispersion, forming hydrophobic interactions with the drug. , There is also evidence that HPMC-AS can stabilize the drug in solution in in vitro systems and, potentially, the gastric milieu, further enhancing the bioavailability of the drug by maintaining it at (or even above, at least temporarily) the saturation solubility of the drug. − …”

Section: Chemical Shift As a Unique Observable Of The Api–polymer Int...mentioning

confidence: 99%

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

et al. 2022

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Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on an amorphous API dispersed in a polymer, and their stability is driven by the presence of strong intermolecular interactions between these two species (e.g., hydrogen bond, electrostatic interactions, etc.). The understanding of these interactions at the atomic level is therefore crucial, and solid-state nuclear magnetic resonance (NMR) has demonstrated itself as a very powerful technique for probing API−polymer interactions. Other reviews have also reported exciting approaches to study the structures and dynamic properties of ASDs and largely focused on the study of API−polymer miscibility and on the identification of API−polymer interactions. Considering the increased use of NMR in the field, the aim of this Review is to specifically highlight recent experimental strategies used to identify API−polymer interactions and report promising recent examples using one-dimensional (1D) and two-dimensional (2D) experiments by exploiting the following emerging approaches of very-high magnetic field and ultrafast magic angle spinning (MAS). A range of different ASDs spanning APIs and polymers with varied structural motifs is targeted to illustrate new ways to understand the mechanism of stability of ASDs to enable the design of new dispersions.

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Section: Chemical Shift As a Unique Observable Of The Api–polymer Int...mentioning

confidence: 99%

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

et al. 2022

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“…These derivative products have shown superior water retention, emulsifying, thickening, gelling and stabilizing capabilities. 6,7 DCPD (CaHPO 4 Á2H 2 O) and OCP (Ca 8 H 2 (PO 4 ) 6 5H 2 O) are two main calcium phosphate bioceramics which are widely used as fillers and coatings in calcified tissues. 8 Researchers stated that these compositions have several advantages in tissue engineering applications due to their biocompatibility, porosity, surface charge density, functionality, solubility, self-setting properties, injectability, unique formability and low degradability compared to other bioceramics.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it can be used as a model system for the gel growth of calcium phosphate because it is a derivative biopolymer from cellulose. 6,7,[11][12][13][14] Therefore, we developed single and double diffusion gel growth methods for in vitro biomineralization of DCPD and OCP to study the mechanism of in vitro biomineralization with cellulose ethers.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxypropyl methylcellulose-controlled in vitro calcium phosphate biomineralization

Gashti¹,

Stir

Burgener

et al. 2022

New J. Chem.

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“…[3][4][5] With the advent of nanotechnology, new forms of pharmaceutical, including nanoparticles, nanobeads, and nanofibers, have been widely used in drug release systems. [6][7][8] The application of nanotechnologies in drug therapy delivery can enhance a controlled release and improve the absorption and availability of drugs. 9,10 Medicated nanofibers have primarily been created by electrospinning.…”

mentioning

confidence: 99%

Dual-functional SFP/PAN based nano drug release system for treatment and nutrients

Han

Dou

et al. 2021

Textile Research Journal

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Nano drug delivery systems can control the ordered release of drugs. To achieve the target of supplying therapeutics and nutrients at the same time, a novel nano drug delivery system with a core–shell structure was prepared by coaxial electrospinning. Polyacrylonitrile (PAN) has been used to produce a drug release scaffold in the shell section, mixed with absorbable silk fibroin peptide (SFP) as a nutrient. Ciprofloxacin (CPFX), a broad-spectrum antibiotic, was used as the core, as well as an antibacterial agent. Owing to its low molecular weight, using a pure SFP thin solution to manufacture nanofibers by electrospinning is still technically challenging. Thus, different ratios of PAN to SFP were used in the shell electrospinning solution. In this research, a novel nano dual-functionality drug delivery system has been successfully prepared. In vitro testing demonstrated that nanofibers could supply more nutrients with increasing SFP in shell solutions; however, the ability to maintain controlled release was reduced. It was found that the nanofiber membrane had the best controlled drug release capability for a PAN-to-SFP mass ratio of 95:5. Overall, most ciprofloxacin was released in the first 12 h, while the release of SFP was constant throughout the first 24 h. Our modeling demonstrated that the release of CPFX and SFP is best described using a first-order kinetic model. The developed drug delivery system is designed to release antimicrobial drugs in a controlled manner and provide absorbable nutrients simultaneously.

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Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole

Cited by 13 publications

References 33 publications

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

Hydroxypropyl methylcellulose-controlled in vitro calcium phosphate biomineralization

Dual-functional SFP/PAN based nano drug release system for treatment and nutrients

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