Application of Hydrogen in Hemodialysis: A Brief Review with Emphasis on the Quantification of Dissolved H2

Mouzakis, Foivos Leonidas; Khadka, Lal Babu; Pereira da Silva, Miguel; Mottaghy, Khosrow

doi:10.1007/978-3-031-47375-3_13

Advances in Biochemistry in Health and Disease

2024

DOI: 10.1007/978-3-031-47375-3_13

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Application of Hydrogen in Hemodialysis: A Brief Review with Emphasis on the Quantification of Dissolved H2

Foivos Leonidas Mouzakis,

Lal Babu Khadka,

Miguel Pereira da Silva

et al.

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Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study

Mouzakis,

Hima,

Kashefi

et al. 2024

Biomedicines

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Extracorporeal circulation (ECC) is frequently implemented in a vast array of modalities such as hemodialysis, cardiopulmonary bypass, extracorporeal membrane oxygenation (ECMO), and others. Patients receiving any such therapy are frequently encumbered with chronic inflammation, which is inherently accompanied by oxidative stress. However, ECC treatments themselves are also responsible for sustaining or promoting inflammation. On these grounds, an in vitro study was designed to investigate the therapeutic potential of molecular hydrogen (H2) against pro-inflammatory agents in ECC settings. Five miniature ECMO circuits and a small vial (Control) were primed with heparinized blood from healthy adult donors (n = 7). Three of the ECMO systems were injected with lipopolysaccharide (LPS), out of which one was additionally treated with an H2 gas mixture. After 6 h, samples were drawn for the assessment of specific biomarkers (MCP-1, MPO, MDA-a, TRX1, and IL-6). Preliminary results indicate a progressive oxidative and inflammatory response between the six systems. Circulation has triggered inflammation and blood trauma, but the staggering influence of LPS in this outcome is indisputable. Accordingly, hydrogen’s remedial potential becomes immediately apparent as biomarker concentrations tend to be lower in the H2-handled circuit. Future research should have distinct objectives (e.g., dosage/duration/cycle of hydrogen administration) in order to ascertain the optimal protocol for patient treatment.

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Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study

Mouzakis,

Hima,

Kashefi

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Application of Hydrogen in Hemodialysis: A Brief Review with Emphasis on the Quantification of Dissolved H2

Cited by 1 publication

References 16 publications

Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study

Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study

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