“…Several techniques of rapid canine retraction can be used as alveolar surgery and distraction osteogenesis (17) which accelerates the bone resorption, and osteoclast activity (35) . Also, because surgical injury to alveolar bone such as corticotomy and MOPs can induce local inflammatory reaction, chemokine and cytokine levels are elevated, hence osteoclast stimulation and tooth movement acceleration (1,36) . However, these techniques involve invasive flap surgery; so, a novel simplified flapless approach was performed to accelerate the rate of canine movement by periodontal ligament distraction which was reported as technique not resulted in damage to the periodontal ligament, nor affected pulp vitality (37) .…”