Application of Hyaluronic Acid Sodium Salt and Vitamin C in the Therapy of Dogs with Hypertrophic Osteodystrophy

Abstract

Radiographic examination of the distal radius and ulna of dogs showed changes in metaphyseal areas of both bones characteristic of hypertrophic osteodystrophy (HOD). The serum of the patients showed increased activity of alkaline phosphatase (ALKP) and elevated concentrations of Ca and P. Oral application of vitamin C and injection of sodium salt of hyaluronic acid in the bolus caused a reduction in swelling, disappearance of pain symptoms around the joints, and increased appetite. Radiographic examinations performed on the 60th d of treatment revealed the withdrawal of the changes characteristic for HOD. The chosen biochemical parameters tested during the treatment showed a decrease in comparison to the values before treatment, namely: ALKP by 27.7%, Ca by 22.2%, P by 12.3%, and Mg by 2.4%. Clinical condition of the animals was defined as good or very good. The use of hyaluronic acid and vitamin C in the treatment of HOD in the first stage of the disease proved to be highly successful, resulting in the inhibition of the disease course.

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“…Growing puppies and adult dogs do not have a dietary requirement for vitamin C, as they have the ability to synthesize it endogenously from other substrates (McDowell, 2000 ; Richardson & Zentek, 1998 ), but short‐term supplementation (on average 5.2 mg/kg body weight, for 36 days) was shown to raise its serum concentration (Hesta et al, 2009 ). When dogs with early stages of hypertrophic osteodystrophy, a developmental bone disease mainly affecting large breeds, were treated with oral vitamin C (40 mg/kg body weight, daily) and injection of sodium salt of hyaluronic acid (20 mg, 5× every 10 days) for 60 days, decreased inflammation and pain around joints, enhanced collagen synthesis, and the disappearance of radiological features of hypertrophic osteodystrophy were observed (Aleksiewicz et al, 2013 ). Treatment effects may be mediated by an increase of bone mineralization as observed by reduced serum calcium and phosphorus concentrations and lowered alkaline phosphatase activity (Aleksiewicz et al, 2013 ).…”

“…When dogs with early stages of hypertrophic osteodystrophy, a developmental bone disease mainly affecting large breeds, were treated with oral vitamin C (40 mg/kg body weight, daily) and injection of sodium salt of hyaluronic acid (20 mg, 5× every 10 days) for 60 days, decreased inflammation and pain around joints, enhanced collagen synthesis, and the disappearance of radiological features of hypertrophic osteodystrophy were observed (Aleksiewicz et al, 2013 ). Treatment effects may be mediated by an increase of bone mineralization as observed by reduced serum calcium and phosphorus concentrations and lowered alkaline phosphatase activity (Aleksiewicz et al, 2013 ). However, the effects of vitamin C alone could not be independently evaluated, and no control group was present for comparison.…”