Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development

Kang, Jiahui; Gong, Jing; Cao, Yang; Lin, Xiao; Yan, Lijuan; Gong, Yu; Xu, Haiwei

doi:10.1007/s12015-023-10553-x

Cited by 3 publications

(2 citation statements)

References 148 publications

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“…Existing RO primarily contain photoreceptor and ganglion cells, but lack vasculature and immune cells, which is a major limitation [ 25 ]. Therefore, adding cell types like vascular endothelial cells and macrophages would aid in reconstituting the cellular composition and immune microenvironment of the retina [ 59 , 60 ]. Retinal pigment epithelial cells can also be incorporated to construct a complete retinal system [ 24 ].…”

Section: Next-generation Retinal Organoidsmentioning

confidence: 99%

“…Moreover, co-culturing different cell types can also promote maturation of retinal cells. For instance, co-culture of retinal ganglion cells with photoreceptor cells can improve the viability and functionality of photoreceptors [ 49 ]; co-culture with vascular endothelial cells enables observing the effect of angiogenesis on retinal cell differentiation [ 53 , 59 , 60 ]. Some studies utilize brain microvascular endothelial cells and neural progenitor cells in co-culture, and find induced expression of pro-angiogenic VEGF can promote neuronal differentiation.…”

Section: Next-generation Retinal Organoidsmentioning

confidence: 99%

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Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Zhao,

Yan

2023

Stem Cell Rev and Rep

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Retinal diseases are leading causes of blindness globally. Developing new drugs is of great significance for preventing vision loss. Current drug discovery relies mainly on two-dimensional in vitro models and animal models, but translation to human efficacy and safety is biased. In recent years, the emergence of retinal organoid technology platforms, utilizing three-dimensional microenvironments to better mimic retinal structure and function, has provided new platforms for exploring pathogenic mechanisms and drug screening. This review summarizes the latest advances in retinal organoid technology, emphasizing its application advantages in high-throughput drug screening, efficacy and toxicity evaluation, and translational medicine research. The review also prospects the combination of emerging technologies such as organ-on-a-chip, 3D bioprinting, single cell sequencing, gene editing with retinal organoid technology, which is expected to further optimize retinal organoid models and advance the diagnosis and treatment of retinal diseases.

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Section: Next-generation Retinal Organoidsmentioning

confidence: 99%

Section: Next-generation Retinal Organoidsmentioning

confidence: 99%

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Zhao,

Yan

2023

Stem Cell Rev and Rep

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Ethanol Causes Cell Death and Neuronal Differentiation Defect During Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids

Gong,

Ge,

et al. 2023

Stem Cell Rev and Rep

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A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases

Beaver,

Limnios

2023

Front. Transplant.

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Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging. In this review, we discuss the potential use of human pluripotent stem cell (hPSC)-derived photoreceptors for the treatment of retinal degeneration and highlight the progress and challenges for their efficient production and clinical application in regenerative medicine.

show abstract

Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development

Cited by 3 publications

References 148 publications

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery

Ethanol Causes Cell Death and Neuronal Differentiation Defect During Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids

A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases

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