Application of Human Amniotic Membrane in Canine Penile Tunica Albuginea Defect: First Step toward an Innovating New Method for Treatment of Peyronie?s Disease

Salehipour, Mehdi; Izadpanah, Kaywan; Safaei, Akbar; Kamranpoor, M; Farsiani, Mohamadreza

doi:10.1590/s1677-5538.ibju.2014.03.15

Cited by 9 publications

(7 citation statements)

References 26 publications

(18 reference statements)

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“…The search for a suitable TA substitute for penile surgery has led to testing materials such as human amniotic membrane, lingual mucosa, and buccal mucosa. 20 26 27 Salehipour et al . 26 have documented good integration of grafted amniotic membrane with surrounding tissue, successful reepithelization, increased collagen fiber deposition, reduction of elastic fibers in the upper portion of the repaired area, and no dysplasia in canine TA defects; however, the authors described no data on possible immunological reactions and their study is limited by a relatively short follow-up (12 weeks).…”

Section: Discussionmentioning

confidence: 99%

Microsurgical tunica albuginea transplantation in an animal model

Sansalone

Loreto

Leonardi³

et al. 2017

Asian J Androl

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Several andrological diseases require surgical repair or reconstruction of tunica albuginea, which envelops the corpora cavernosa penis. Despite intense research efforts involving a variety of biological materials, such as skin, muscle aponeurosis, human dura mater, tunica vaginalis, and pericardium, engineered tunica albuginea suitable for graft use is yet to be obtained. The study investigates microsurgical tunica albuginea allotransplantation in an animal model with the purpose of creation of an organ-specific tissue bank to store penile tissue, from cadaveric donors and male-to-female trans-sexual surgery, for allogeneic transplantation. Materials were tunica albuginea tissue explanted from 15 donor rats, cryopreserved at −80°C, gamma-irradiated, and implanted in 15 recipient rats, of which three rats were used as controls. Penile grafts were explanted at different time intervals; after macroscopic evaluation of the organ, the grafts were processed to morphological, histochemical, and immunohistochemical examinations by light microscopy. Detection of pro-inflammatory cytokines was also performed. Examination of the tunica albuginea allografts collected 1, 3, or 6 months after surgery and of control tunica albuginea fragments showed that tunica albuginea implants achieved biointegration with adjacent tissue at all-time points. The integration of cryopreserved rat tunica albuginea allografts, documented by our study, encourages the exploration of tunica albuginea allotransplantation in humans. In conclusion, the effectiveness and reliability of the tunica albuginea conditioning protocol described here suggest the feasibility of setting up a tunica albuginea bank as a further tissue bank.

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Section: Discussionmentioning

confidence: 99%

Microsurgical tunica albuginea transplantation in an animal model

Sansalone

Loreto

Leonardi³

et al. 2017

Asian J Androl

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“…Twelve weeks later, histopathologic evaluation of the grafted site showed normal epithelial and collagen healing suggesting this type of graft for future trials in humans. Nonetheless, not before extensive research on a larger cohort of patients, will we be able to confirm the feasibility and safety of this type of graft? 37 …”

Section: Postoperative Considerations: (Surgical Outcomes/patient Rehabilitation)mentioning

confidence: 99%

A decade of grafting techniques as a sole treatment for Peyronie’s disease

2020

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Background Peyronie's disease (PD) can be a cosmetically and functionally devastating condition. Surgical approaches have been proposed in the chronic stages of PD as plication or plaque incision/excision with grafting to preserve penile size in complex cases. Although several surgeons nowadays are inclined toward the utilization of non‐autologous grafts owing to the ease of their preparation and availability, synthetic graft procedures still await more technical improvements and supporting evidence before their consideration for standard care. Objectives In this review, our goal is to facilitate an insight into the most promising grafting materials used for the management of PD and techniques associated. Materials and methods A PubMed review was conducted for all the studies on our topic within the past ten years (January 2009 until December 2019). The outcome parameters we documented and compared comprised of operative time, follow‐up time, postoperative penile cosmesis and function, and, finally, overall patient satisfaction related to each technique. Results Our search yielded 23 English‐written original study articles in addition to a single case report on the various grafting techniques utilized as the sole treatment for PD, each demonstrating different outcomes and points of comparison. Conclusion A successful grafting procedure for PD requires an appropriately tailored surgical modality and an experienced surgeon. Nevertheless, proper preoperative patient counseling on all aspects of his condition and opted treatment modality while setting clear and realistic expectations remains key for overall patient satisfaction.

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“…The ability of dHACM to adapt to host tissue characteristics makes it an ideal substitution for the tunica albugenia. In their canine model, Salehipour et al ( 19 ) found that dHACM grafts showed increased distensibility and elasticity post-operatively. This was confirmed by the presence of elastin fibers on histopathologic examination.…”

mentioning

confidence: 99%

“…This was confirmed by the presence of elastin fibers on histopathologic examination. During subsequent stimulation of artificial erections, the dHACM was able to tolerate high intra-cavernosal pressures without leaking or bulging ( 19 ). This characteristic of dHACM may make it the ideal substitution graft for penile reconstructive surgery.…”

mentioning

confidence: 99%