Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress

Xiang, Wei; Lam, Yi; Periyasamy, Giridharan; Chuah, Charles

doi:10.3390/ijms23052863

Cited by 1 publication

(2 citation statements)

References 61 publications

(81 reference statements)

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“…AML is characterized by aberrant differentiation and abnormal clonal expansion of myeloid blasts ( Newell and Cook 2021 ; Xiang et al, 2022 ). It has been reported that dysregulated circRNAs can regulate cell differentiation, cell cycle progression and cell proliferation through acting as microRNA sponges in various diseases ( Xiao et al, 2021 ; Shi et al, 2022 ; Wang et al, 2022 ).…”

Section: Circrnas Regulte Cell Differentiation Cell Cycle Progression...mentioning

confidence: 99%

“…AML has become a central research focus because it is the most common type of acute leukemia in adults worldwide, with rising morbidity and mortality ( Gallipoli et al, 2015 ; Liu et al, 2019 ; Bhattacharya and Gutti 2022 ). The key therapeutic strategies for AML include chemotherapy, allogenic hematopoietic stem cell transplantation and palliative care ( Xiang et al, 2022 ). However, although these advancements in the treatment of AML, the overall prognosis is poor (5-yeal overall survival only 28.7%) ( Singh V. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Functions and clinical significance of circular RNAs in acute myeloid leukemia

et al. 2022

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Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML.

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