Application of High Performance Liquid Chromatography Method for Triadimenol Analysis in Water Sample

Hermawan, Dadan; Cacu,; Suwandri,; Fatoni, Amin; Mudasir, Mudasir; Aboul‐Enein, Hassan Y.

doi:10.1088/1742-6596/1494/1/012032

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The precision test expressed as relative standard deviation (RSD) has been evaluated, measuring in six repetitions using the standard solution of econazole 50 mg/L. This test uses the principle of repeatability in which the test is carried out on the same day at the same equipment condition, solvent, and analysis (Hermawan et al, 2020). Based on the test results, the first and second peak enantiomeric standard deviation values were 0.42 and 0.22, respectively.…”

Section: Precisionmentioning

confidence: 99%

Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

Hermawan

Cacu²,

Salsabila³

et al. 2022

molekul

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The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitrile : water (0.2% HCOOH) (20:80, v/v), and UV detection of 220 nm.The optimized HPLC method has been applied for the quantitative determination of econazole in the pharmaceutical (liquid) sample withpercentage recovery of 100.75 % (RSD = 0,95%; n = 3). The effect of several HPLC parameters on the chiral separation of econazole was also evaluated and the method was successfully validated in terms of linearity, accuracy, precision, and selectivity. The present HPLC method was simple, short analysis time, and high resolution.

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Section: Precisionmentioning

confidence: 99%

Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

Hermawan

Cacu²,

Salsabila³

et al. 2022

molekul

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“…Therefore, it is extensively applied to agricultural production [6]. The detection methods of triazole pesticides mainly include HPLC [7–9], LC‐MS/MS [10, 11], and so on, which mainly detect the raceme of triazole fungicides. Triazole fungicides contain one or two chiral centers, and two or four enantiomers [12].…”

Section: Introductionmentioning

confidence: 99%

Separation and determination of triadimefon and its metabolites triadimenol enantiomers in fruit puree by supercritical fluid chromatography

Zhang¹,

Hou³

et al. 2023

J of Separation Science

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A method was established for the separation and determination of triadimefon and its metabolite triadimenol enantiomer residues in major complementary fruit puree for infants and young children (banana puree, pineapple puree, and grape puree) by supercritical fluid chromatography. After the samples were extracted with acetonitrile and purified with a solid phase extraction cartridge, Acquity Trefoil CEL2 chiral chromatographic column was adopted for separation, and gradient elution was conducted at the flow rate of 1.0 ml/min under the mobile phase of supercritical carbon dioxide -0.5% ammonia methanol, the detection wavelength was 220 nm and quantification was conducted with the external standard method. The limits of quantitation of triadimefon and triadimenol enantiomers were both 0.05 mg/kg, the linear ranges were 0.5-50 mg/L, and the linear correlation coefficients were greater than 0.9993. The recoveries in the spiked samples at 0.05, 0.2, and 3.0 mg/kg were from 80.1 to 106%, and the relative standard deviation reached 3.3-7.6%. The method is efficient, rapid, reproducible, and environmentally friendly, enabling accurate analysis of pesticide enantiomers, which can detect the enantiomer residues of triadimefon and its metabolite triadimenol in major complementary fruit puree for infants and young children.

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Application of High Performance Liquid Chromatography Method for Triadimenol Analysis in Water Sample

Cited by 2 publications

References 8 publications

Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

Separation and determination of triadimefon and its metabolites triadimenol enantiomers in fruit puree by supercritical fluid chromatography

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