Application of Hepatic Transit Time and Shear Wave Velocity in Assessing Portal Pressure in Patients with Cirrhotic Portal Hypertension

Lin, Yuanqiang; Liu, Yan; Jiang, Bo; Li, Wenhui; Li, Hequn; Wang, Hui

doi:10.1016/j.ultrasmedbio.2020.10.001

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The risk factors of hypertension are positively correlated with hypertension. Increased left atrial diameter and high portal vein velocity are common symptoms associated with hypertension [37,38]. L-Alphaaminobutyric acid and Isocitric acid have not been considered risk markers for hypertension in the past.…”

Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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Background Hypertension is a kind of clinical syndrome, characterized by the increase of systemic arterial pressure. There is a lack of identifiable triggers and predictors of hypertensive disease in response to treatment at rest and during exercise. In this study, a mathematical model was used to screen and compare the indicators and related changes at rest and during exercise between normotensive and hypertensive individuals. Methods Blood pressure and ultrasound-related indicators, blood biochemical indicators and metabolic compounds were collected and logistic regression model and Principal component analysis (PCA) were used to explore the differences of indexes at rest and in different exercise states in healthy and hypertensive patients. An indicator change map for hypertension is established. Results The results reveal that hypertension is not only related to oxidative stress, inflammatory reaction and fatty acid oxidation, but also involves various amino acid metabolism. The defined mathematical models and indicators changes during exercise might be helpful for early screening of hypertension and future studies are needed to explore their value on prevention and control of hypertension. Conclusion The research shows that the main regulation indicators at different exercise states differ significantly in the normal group and the hypertensive group. The key indicators of the normal group are blood pressure and ultrasound related indicators, while those of the hypertensive group are metabolites related to lactic acid metabolism, glycolysis, aerobic oxidation and lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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show abstract

“…At this time, HVPG is only a surrogate marker of directly measured portal pressure, and the prediction of portal pressure may be meaningful. In this regard, a more recent study reported the correlation between portal pressure and parameters of CEUS, including hepatic artery-to-hepatic vein transit time (HA-HVTT), portal vein-to-hepatic vein transit time (PV-HVTT), and liver parenchyma-to-hepatic vein transit time ( 21 ). However, as the AUROC and cutoff value to detect specific pressure were not investigated in this study, the practical value of CEUS for assessing portal venous pressure needs to be further evaluated.…”

Section: Us Based On Circulating Microbubblesmentioning

confidence: 99%

Contrast-enhanced ultrasonography for the management of portal hypertension in cirrhosis

Maruyama

Tobari²,

Nagamatsu³

et al. 2022

Front. Med.

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Portal hypertension is a major pathophysiological condition in patients with cirrhosis. This accounts for the occurrence and severity of the various manifestations. The degree is determined by the portal pressure or hepatic venous pressure gradients, both of which are obtained by invasive interventional radiological procedures. Ultrasound (US) is a simple and minimally invasive imaging modality for the diagnosis of liver diseases. Owing to the availability of microbubble-based contrast agents and the development of imaging modes corresponding to contrast effects, contrast-enhanced US (CEUS) has become popular worldwide for the detailed evaluation of hepatic hemodynamics, diffuse liver disease, and focal hepatic lesions. Recent advancements in digital technology have enabled contrast-based demonstrations with improved resolution, leading to a wider range of applications. This review article describes the current role, benefits, and limitations of CEUS in the management of portal hypertension.

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Application of Hepatic Transit Time and Shear Wave Velocity in Assessing Portal Pressure in Patients with Cirrhotic Portal Hypertension

Cited by 2 publications

References 32 publications

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Contrast-enhanced ultrasonography for the management of portal hypertension in cirrhosis

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