Application of green and recyclable menthol-based hydrophobic deep eutectic solvents aqueous for the extraction of main taxanes from Taxus chinensis needles

Menthol-assisted homogenous liquid-liquid microextraction for HPLC/UV determination of favipiravir as an antiviral for COVID-19 in human plasma

“…The chemical structure of menthol shows a polar hydroxyl group and a nonpolar chain of carbons, which could urge the menthol molecules to aggregate in the form of reverse micelle to decrease contact surface with the organic extractant. The surfactant-like properties of menthol and the ability to form micelles have been previously reported [23] , [24] . This interesting property could be exploited to extract hydrophilic analytes, such as favipiravir, which could be entrapped in the polar core of the reverse micelle and be eventually extracted from the aqueous sample.…”

Advancements in the Cultivation, Active Components, and Pharmacological Activities of Taxus mairei

“…[ 19 , 36 ]. Among them, the content of 10-Deacetylbaccatin III, 7-Xyl-10-DAT, and 10-Deacetyltaxol is relatively high, with studies determining their respective content to be approximately 626 µg/g, 546 µg/g, and 236 µg/g [ 37 ]. However, the content of these compounds may vary significantly depending on biological age, collection time, and other differing quantities of secondary metabolites.…”

Structural and dynamic properties of eutectic mixtures based on menthol and fatty acids derived from coconut oil: a MD simulation study

“…Marrucho et al have reported several Hydrophobic deep eutectic solvents composed of natural, nontoxic compounds, i.e., terpenes and fatty acids 10 . Menthol-based hydrophobic DESs have lower viscosity and higher volatility than hydrophobic quaternary-ammonium based DESs 5 . Furthermore, it is easy to recover target compounds from menthol based DESs.…”

“…Eutectic mixtures have melting points much lower than their individual components. The volatile organic solvents, such as including methanol, ethanol, and chloroform 5 , due to their extensive usage in the industry, give rise to various diseases. Therefore, to ensure better human health, ionic liquids (ILs) have attained great attention as an alternative to these toxic solvents including methanol, ethanol, and chloroform 5 .…”

“…Since 2015, Hydrophobic DES was receiving a great amount of has been studied extensively due to the stable hydrophobic phase in contact with water and inexpensive and natural components that follows the principles of green chemistry 5 . Previous studies show that the hydrophobic DESs based on quaternary ammonium halides salt are able to extract of hydrophobic phytochemicals, such as artemisinin and polyprenyl acetates, from plant materials 8 , 9 .…”