Application of gold nanoparticles to microencapsulation of thioridazine

Lai, Mei-Kuan; Chang, Ching-Yu; Lien, Yi-Wen; Tsiang, Raymond Chien‐Chao

doi:10.1016/j.jconrel.2005.12.017

Cited by 29 publications

(17 citation statements)

References 28 publications

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“…Gold nanoparticles are mostly dispersed and immobilized on a surface or inside of cellulosic supporting material, such as films or membranes (Kumar et al 2009;Liu et al 2010;Loskutov et al 2009), fibers (Li and Taubert 2009;Pinto et al 2007;Yokota et al 2008), nanocrystals (Shin et al 2008), microcapsules (Lai et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Radially oriented cellulose triacetate chains on gold nanoparticles

et al. 2010

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Cellulose triacetate (CTA) derivatives having a disulfide group at the reducing-end (CTA2S, CTA13S, CTA41S), with number average degrees of polymerization (DP n s) of 2, 13 and 41, respectively, were prepared. The CTA-self-assembled gold nanoparticles (CTA2Au, CTA13Au, and CTA41Au) were obtained through the reduction of gold salt (HAuCl 4 ) with CTASs. The diameters (d) and the interparticle distances (L) of the gold cores were analyzed by transmission electron microscopy (TEM) observations. The d values of CTA2Au, CTA13Au, and CTA41Au, were 8.7, 7.9, and 13.4 nm respectively. The L values of CTA2Au, CTA13Au, and CTA41Au, were 2.8, 6.3, and 20.9 nm, respectively, and agreed well with the molecular length (l) of CTAS chains (ls of CTA2S, CTA13S, CTA41S = 2.0, 7.5, 21.5 nm, respectively). The hydrodynamic diameters (D) of CTAAu nanoparticles in chloroform solution, measured by dynamic light scattering (DLS), were larger than the d values and increased with the increase in the molecular length of the CTA chains. The CTAS chain was found to work as an excellent stabilizer of the gold nanoparticles in both solid state and solution. The molecular length of CTA chains controlled the size and the alignment of the gold nanoparticles. As a result, the radially oriented CTA chains on the gold nanoparticles were successfully prepared.

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Section: Introductionmentioning

confidence: 99%

Radially oriented cellulose triacetate chains on gold nanoparticles

et al. 2010

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“…Therefore, it is critical to correlate the PNB generation with the release of the liposome load, requiring direct detection and monitoring of the PNBs in individual liposomes. Unlike previous attempts where laser-heated NPs were used without detection of bubbles nor monitoring of the release process in individual liposomes, [1,6-9] we have provided the direct imaging of PNBs.…”

Section: Resultsmentioning

confidence: 99%

“…The most advanced approach to the problem of delivery of toxic agents is based on their temporal encapsulation, delivery of the capsule to the target and controlled release from the capsule upon the delivery. Microscale sized, drug-carrying capsules composed of lipids or multiple polyelectrolyte layers have made it possible to deliver drugs slowly over time [1,2]. More recently it has become possible to control the release of drugs or onset of treatment until the microcapsules are in the desired place.…”

Section: Introductionmentioning

confidence: 99%

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Optically guided controlled release from liposomes with tunable plasmonic nanobubbles

Anderson

Hansen

Lukianova‐Hleb

et al. 2010

Journal of Controlled Release

106

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A new method of optically guided controlled release was experimentally evaluated with liposomes containing a molecular load and gold nanoparticles (NPs). NPs were exposed to short laser pulses to induce transient vapor bubbles around the NPs, plasmonic nanobubbles, in order to disrupt the liposome and eject its molecular contents. The release efficacy was tuned by varying the lifetime and size of the nanobubble with the fluence of the laser pulse. Optical scattering by nanobubbles correlated to the molecular release and was used to guide the release. The release of two fluorescent proteins from individual liposomes has been directly monitored by fluorescence microscopy, while the generation of the plasmonic nanobubbles was imaged and measured with optical scattering techniques. Plasmonic nanobubble-induced release was found to be a mechanical, nonthermal process that requires a single laser pulse and ejects of the liposome contents within a millisecond timescale without damage to the molecular cargo and that can be controlled through the fluence of laser pulse.

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“…After 48 h of up to 100 µm gold-nanoparticle treatment, RAW264.7 macrophage cells showed greater than 90% viability with no increase in proinflammatory cytokines TNF-a and IL-1b and the overall cell viability decreased to 85% after 72 h [40]. For gold nanorods, the cytotoxicity could be attributed to the presence of the future science group stabilizer cetyl trimethylammonium bromide of which even residual presence after washing resulted in considerable cytotoxicity [41].…”

Section: "With the Increase In Potential Usefullness Of Nanoparticlesmentioning

confidence: 99%