Application of genetically engineered Salmonella typhimurium for interferon-gamma–induced therapy against melanoma

Yoon, Woo Young; Park, Yoo Chang; Kim, Jinseok; Chae, Yang Seok; Byeon, Jung Hye; Min, Sang Hyun; Park, Sungha; Yoo, Young; Park, Yong Keun; Kim, Byeong Mo

doi:10.1016/j.ejca.2016.10.010

Cited by 82 publications

(37 citation statements)

References 39 publications

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“…Several cytokines, including GM-CSF, IL-12, and IL-18, have entered clinical trials for cancer therapy 136 . Cytokines expressed by tumor-targeting bacteria were delivered specifically to the tumor region, where they augmented the antitumor immune response in the TME 20,29,49,62,137–140 . Intravenous administration of an IL-18-expressing attenuated S .…”

Section: Engineering Of Bacteriamentioning

confidence: 99%

Bacteria-cancer interactions: bacteria-based cancer therapy

et al. 2019

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Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy, have raised the hope for cures for many cancer types. However, there are still ongoing challenges to the pursuit of novel therapeutic approaches, including high toxicity to normal tissue and cells, difficulties in treating deep tumor tissue, and the possibility of drug resistance in tumor cells. The use of live tumor-targeting bacteria provides a unique therapeutic option that meets these challenges. Compared with most other therapeutics, tumor-targeting bacteria have versatile capabilities for suppressing cancer. Bacteria preferentially accumulate and proliferate within tumors, where they can initiate antitumor immune responses. Bacteria can be further programmed via simple genetic manipulation or sophisticated synthetic bioengineering to produce and deliver anticancer agents based on clinical needs. Therapeutic approaches using live tumor-targeting bacteria can be applied either as a monotherapy or in combination with other anticancer therapies to achieve better clinical outcomes. In this review, we introduce and summarize the potential benefits and challenges of this anticancer approach. We further discuss how live bacteria interact with tumor microenvironments to induce tumor regression. We also provide examples of different methods for engineering bacteria to improve efficacy and safety. Finally, we introduce past and ongoing clinical trials involving tumor-targeting bacteria.

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Section: Engineering Of Bacteriamentioning

confidence: 99%

Bacteria-cancer interactions: bacteria-based cancer therapy

et al. 2019

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“…For example, Salmonella typhimurium expressing and secreting recombinant IFN-γ demonstrated enhanced tumoricidal effect and prolonged the survival of melanoma tumor bearing syngeneic mouse model. The IFN-γ directly activated the NK cell and the macrophages leading to more effective tumor suppression [ 95 ]. Commercially available bioproduct of Staphylococcus aureus metabolites (consisting of enterotoxins, proteins, and amino acids) was found to be effective in the treatment of mesothelioma in orthotopic mouse models.…”

Section: Mechanism Of Tumor Suppressionmentioning

confidence: 99%

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Sawant

Patil

Gupta

et al. 2020

IJMS

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Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and radiation and are often non-specific in action. The development of drug resistance and the inability of the drug to penetrate the tumor cells has been a major pitfall in current treatment. This has led to the investigation of alternative anti-tumor therapeutics possessing greater specificity and efficacy. There is a significant interest in exploring the use of microbes as potential anti-cancer medicines. The inherent tropism of the bacteria for hypoxic tumor environment and its ability to be genetically engineered as a vector for gene and drug therapy has led to the development of bacteria as a potential weapon against cancer. In this review, we will introduce bacterial anti-cancer therapy with an emphasis on the various mechanisms involved in tumor targeting and tumor suppression. The bacteriotherapy approaches in conjunction with the conventional cancer therapy can be effective in designing novel cancer therapies. We focus on the current progress achieved in bacterial cancer therapies that show potential in advancing existing cancer treatment options and help attain positive clinical outcomes with minimal systemic side-effects.

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“…Synthetic biological circuits developed in lab strains of E. coli [22] have shown to be easily ported to probiotic EcN for therapeutic applications [23]. While a few other non-probiotic Gram-negative strains are also being explored as therapeutic vehicles ( Salmonella enterica serovar Typhimurium [24], Bacteroides fragilis [25], and Bacteroides thetaiotaomicron [26]), food-grade probiotic Gram-positive LAB may be more desirable as oral or mucosal therapeutic delivery vectors since they are inherently non-pathogenic and can survive traversal through the harsh gastric environment. Thus, much application focus has been placed on using LAB to treat idiopathic GI disorders that have few current treatment options or as mucosal vaccines, which are promising alternatives to parenteral injections.…”

Section: Lab Therapeutics Currently In Developmentmentioning

confidence: 99%

Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics

Mays

Nair

2018

Current Opinion in Biotechnology

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The trillions of microbes hosted by humans can dictate health or illness depending on a multitude of genetic, environmental, and lifestyle factors that help define the human ecosystem. As the human microbiota is characterized, so can the interconnectivity of microbe-host-disease be realized and manipulated. Designing microbes as therapeutic agents can not only enable targeted drug delivery but also restore homeostasis within a perturbed microbial community. Used for centuries in fermentation and preservation of food, lactic acid bacteria (LAB) have a long history of safe, and occasionally health promoting, interactions with the human gut, making them ideal candidates for engineered functionality. This review outlines available genetic tools, recent developments in biomedical applications, as well as potential future applications of synthetic biology to program LAB-based therapeutic systems.

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Application of genetically engineered Salmonella typhimurium for interferon-gamma–induced therapy against melanoma

Cited by 82 publications

References 39 publications

Bacteria-cancer interactions: bacteria-based cancer therapy

Bacteria-cancer interactions: bacteria-based cancer therapy

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics

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