Application of General Unified Threshold Models to Predict Time-Varying Survival of Mayfly Nymphs Exposed to Three Neonicotinoids
Vanessa S. C. Lourenço,
Neusa L. Figueiredo,
Michiel A. Daam
Abstract:Pesticide exposure patterns tested in laboratory bioassays often do not match real-world pesticide exposure profiles in edge-of-field waterbodies. Toxicokinetic–toxicodynamic (TKTD) models are therefore increasingly used, as they allow for predictions of the toxic effects under actual time-variable field exposures. The TKTD models from the General Unified Threshold models of Survival (GUTS), for example, are considered ready for use by regulators for calculating the survival rates for any time-variable exposur… Show more
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