This study introduces the implementation of fuzzy set theory to solve machine layout design issues, in order to handle vague information, using a genetic algorithm with tournament selection as the selection operator. The material handling inputs, including frequency and volume of materials that move between machines, were the parameters regarded as fuzzy numbers. The experimental results came from 2 case studies in a manufacturing system. In the first case, examining the difference in shapes of the triangular membership functions of input data, the total distances were reduced from 38.45 m to 29.72 m, a 22.71% reduction in distance. In the second case, examining the uncertainty of fuzzy data by an expert, the total distances were reduced from 103.45 m to 82.45 m, a 20.03% reduction in distance. It was found that given the uncertainty in input data, a shorter total material handling distance might not give a lower cost. The selection operator of tournament selection can compete effectively to converge to near the optimum solution. This can, therefore, be an alternative technique in managing manufacture.