Application of functional near-infrared spectroscopy in psychiatry

Ehlis, Ann‐Christine; Schneider, Sabrina; Dresler, Thomas; Fallgatter, Andreas J.

doi:10.1016/j.neuroimage.2013.03.067

Cited by 233 publications

(186 citation statements)

References 166 publications

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“…We can thus infer that the hypertensive group was demonstrating increased neuronal activation in the PFC despite a relatively impaired behavioral performance. Increases in neuronal activation on cognitive tasks in healthy and diseased populations have been previously observed in fNIRS activation studies [44], as well as similar fMRI [45] and PET studies [46]. In this study, however, the higher O 2 Hb levels for the hypertensive group suggest the possibility of a higher neuronal activation-rate when compared to normotensives.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 69%

Hemodynamic changes in the prefrontal cortex during working memory in essential hypertension

Grant

Bhambhani

Singhal

2015

Journal of the American Society of Hypertension

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 69%

Hemodynamic changes in the prefrontal cortex during working memory in essential hypertension

Grant

Bhambhani

Singhal

2015

Journal of the American Society of Hypertension

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“…The mean K represents the network density, in which the network connections are sparse when the average node degree is small. Meanwhile, functional near‐infrared spectroscopy (fNIRS) is a noninvasive and affordable neuroimaging technique (Ehlis, Schneider, Dresler, & Fallgatter, 2014; Ferrari & Quaresima, 2012; Vanderwert & Nelson, 2014), which utilize the near‐infrared light (wavelengths between 680–950 nm) to inspect the brain activation by measuring the concentration changes of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) (Ferrari & Quaresima, 2012; Jobsis, 1977; Villringer & Chance, 1997). fNIRS studies have been conducted to reveal the neural mechanisms underlying various cognitive tasks (He, Wang, Li, & Yuan, 2017; Lu, Wang, Zhang, Chen, & Yuan, 2017; Wang, Lu, Hu, Zhang, & Yuan, 2018).…”

Section: Introductionmentioning

confidence: 99%

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Wang

Zhang

et al. 2018

Brain and Behavior

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BackgroundAccumulating evidence shows that the dorsal lateral prefrontal cortex (dlPFC) is implicated in personality traits. In this study, resting‐state functional near infrared spectroscopy (fNIRS) combined with small‐world analysis was utilized to examine the relationship between the network properties of dlPFC and personality traits.MethodsThirty college students (aged between 20 and 29) were recruited from the University of Macau campus, whose personality scores were accessed with the NEO‐FFT questionnaire. Graph theory combined with resting‐state fNIRS data was used to quantify the network properties of dlPFC, whereas Pearson correlation analysis was performed to generate the relationship between the small‐world indicators and personality scores.ResultsCompared to matched random networks, the resting‐state brain networks exhibited a larger clustering coefficient (C p, 0.1–0.66), shorter characteristic path length (L p, 0.1–0.66), and higher global (E g, 0.1–0.66) and local efficiency (E loc, 0.1–0.65). In particular, conscientiousness (r = −0.63) and neuroticism (r = 0.40) respectively showed negative and positive correlation with the L p.ConclusionsThe resting‐state functional brain networks in dlPFC exhibited the small‐world properties. In addition, participants with higher conscientiousness scores showed a shorter L p.

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“…Intrasubject reproducibility of frontal activation during the VFT measured via NIRS has been demonstrated in healthy adults at intervals of 2 months [14]. Furthermore, considerable research on the VFT using NIRS imaging indicates hypofrontality in patients with various psychiatric disorders such as schizophrenia, mood disorders, anxiety disorders and eating disorders compared to healthy volunteers [15,16,17] (see review by Ehlis et al [18]). NIRS imaging studies examining the relationship between prefrontal activity and the level of functioning have indicated that prefrontal activation during the VFT is associated with subjective quality of life scores in healthy adults [19], and global functioning in patients with major depressive disorder and schizophrenia [17,20].…”

Section: Introductionmentioning

confidence: 99%

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Nishimura¹,

Takahashi²,

Ohtani³

et al. 2015

Neuropsychobiology

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Background: It is important to understand the neural basis of functional impairments in patients with bipolar disorder (BD) in order to be able to address the recovery. Recently, neurocognitive impairment emerged as a predictor of psychosocial function. A number of functional brain imaging studies have shown that social function is associated with activation of the prefrontal cortex during a cognitive task in healthy adults, and in patients with major depressive disorder and schizophrenia. However, few studies have been conducted in patients with BD. Methods: We performed multichannel near-infrared spectroscopy (NIRS) imaging to investigate the activation of the prefrontal cortex during a verbal fluency task (VFT). We also used the Social Adaptation Self-Evaluation Scale (SASS) to assess social functioning in patients with BD. Thirty-three depressed patients with BD and 65 age-, gender- and task performance-matched healthy controls (HCs) participated in this study. Results: Depressed patients with BD showed reduced activation in the broader bilateral prefrontal cortex during the VFT compared to HCs. Moreover, a significant positive correlation was observed between the total SASS scores and right prefrontal activation in patients with BD. In the SASS subscores, the interest and motivation factor was also positively correlated with frontopolar activation. Conclusions: These results suggest an association between social function and prefrontal activation in depressed patients with BD. The present study provides evidence that NIRS imaging could be helpful in understanding the neural basis of social function.

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Application of functional near-infrared spectroscopy in psychiatry

Cited by 233 publications

References 166 publications

Hemodynamic changes in the prefrontal cortex during working memory in essential hypertension

Hemodynamic changes in the prefrontal cortex during working memory in essential hypertension

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

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