As result, previously non-salvageable limbs have been salvaged. However, there are many patients who require limb amputation. Circumstances of limb amputation may vary, including war wound, infections and animal bites, and traffic accidents and various diseases [2, 3]. In this chapter, I describe general remarks regarding limb amputations, which may help to better understand the following chapters. 2. Types and incidence of amputation. Although the term "amputation" is usually used for the removal of a limb, the removal of other prominent parts of the body, such as the ear, nose, breast, and penis, is also called amputation [4, 5]. However, the population of limb amputees is largest, and an estimated 1.6 million persons were living with the loss of a limb in the USA in the year 2005 [6]. Males are more likely to require limb amputation (a male to female ratio of 1.6-3.9:1), because males are more outgoing and are more prone to trauma, and peripheral artery disease [7]. Lower limb amputation is six-seven times more frequent than upper limbs one [8].