Application of Fluorescein Angiography in Retinoblastoma

Ohnishi, Yoshitaka; Yamana, Y; Minei, M; Ibayashi, Hiroko

doi:10.1016/s0002-9394(14)77372-6

Cited by 15 publications

(12 citation statements)

References 8 publications

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“…Both cases demonstrated decreased intrinsic tumor vascularity and reduced dilation of draining and feeder vessels, especially seen in case 1, in which some areas of the intrinsic tumor vascularity were completely replaced with dark areas, representing zones of no vascular flow. These vascular changes have been reported on FA by other authors [6][7][8]. These findings also correlate with OCT B-scans, as shown in case 1, where the initially elevated hyperdense intraretinal lesion with distinct borders transforms into a not well-limited lesion with atrophic appearance at 1 month from the first TTT session, as has previously been reported [1,3,4].…”

Section: Discussionsupporting

confidence: 89%

“…Retinoblastoma relapse was seen in case 3. Tumor relapses have previously been described on FA as having prominent vessels stemming from a scar adjacent to the tumor relapse [6]. OCTA obtained prior to TTT demonstrated prominent vascularity that was no longer evident on repeat OCTA imaging immediately following TTT treatment.…”

Section: Discussionmentioning

confidence: 84%

“…There are several reports in the literature describing the appearance of active retinoblastoma tumors, preretinal seeds, and the characteristic findings of early small lesions using these imaging modalities [1,3,4]. On FA, retinoblastoma tumors may demonstrate large and small retinal vessel abnormalities and intrinsic tumor vessels [5]; serial FA images can be used to monitor vascular changes after treatment and, in some cases, identify early recurrences [6][7][8]. However, FA is invasive and largely relies on the IV injection of fluorescein dye.…”

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors

Fernández¹,

Haider²,

Vajzovic³

et al. 2021

Ocul Oncol Pathol

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Introduction: The purpose of this study is to describe variations in microvasculature before and after treatment of treatment-naive lesions and during consolidation therapy of retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. Methods: This study is a single-center, prospective, observational case series. Recruited subjects were either undergoing surveillance for retinoblastoma or had newly detected retinoblastoma. Nine tumors from 7 eyes in 6 patients were included. During exams under anesthesia, the tumors were imaged with an investigational portable OCTA system. OCTA images were analyzed to assess vascular changes before and after treatment. Results: In all 6 presented cases, OCTA imaging revealed distinctive vascular patterns, such as dilated feeder arteries and draining veins, disorganized and complex branching patterns, irregular vessel calibers, and dilation and tortuosity of vessels. After treatment, OCTA imaging revealed decreased intrinsic tumor vascularity and reduced dilation of draining and feeder vessels. Tumor relapse demonstrated prominent vascularity (n = 1) that resolved on repeat OCTA after transpupillary thermotherapy treatment. Type 2 (n = 1), 3 (n = 6), and 4 (n = 1) tumor regression patterns were seen in our patients after treatment, and OCTA findings were consistent with a previously published report. Interestingly, in one of the presented cases, OCTA demonstrated clear feeder, draining, and intrinsic tumor vessels that were not as evident on fluorescein angiography. Conclusions: OCTA may offer a noninvasive and sensitive technique to evaluate the vasculature of both the tumor and the surrounding retina in retinoblastoma. With additional research and development into its use in patients with retinoblastoma, OCTA may one day be useful in assessing treatment response and residual tumor activity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors

Fernández¹,

Haider²,

Vajzovic³

et al. 2021

Ocul Oncol Pathol

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“…(i) At presentation, to detect subclinical iris neovascularization (Kim et al, 2014) and assess the tumoral and retinal vascularization status (Ohnishi et al, 1982).…”

Section: Fundus Documentation and Fluorescein Angiographymentioning

confidence: 99%

“…(iv) In case of suspicion of relapse, especially in the context of type II and III regression patterns, by revealing tumor neovascularization (Ohnishi et al, 1982;Shields et al, 1982).…”

Section: Fundus Documentation and Fluorescein Angiographymentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

160

157

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Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be violated. Over the last two decades, conservative management of retinoblastoma witnessed an impressive acceleration of improvements, culminating in two major paradigm shifts in therapeutic strategy. Firstly, the introduction of systemic chemotherapy and focal treatments in the late 1990s enabled radiotherapy to be progressively abandoned. Around 10 years later, the advent of chemotherapy in situ, with the capitalization of new routes of targeted drug delivery, namely intra-arterial, intravitreal and now intracameral injections, allowed significant increase in eye preservation rate, definitive eradication of radiotherapy and reduction of systemic chemotherapy. Here we intend to review the relevant knowledge susceptible to improve the conservative management of retinoblastoma in compliance with the "state of metastatic grace", with particular attention to (i) reviewing how new imaging modalities impact the frontiers of conservative management, (ii) dissecting retinoblastoma genesis, growth patterns, and intraocular routes of tumor propagation, (iii) assessing major therapeutic changes and trends, (iv) proposing a classification of relapsing retinoblastoma, (v) examining treatable/preventable disease-related or treatment-induced complications, and (vi) appraising new therapeutic targets and concepts, as well as liquid biopsy potentiality.

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Retinoblastoma

Green

1985

Diagnosis and Management of Malignant Solid Tumors in Infants and Children

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Application of Fluorescein Angiography in Retinoblastoma

Cited by 15 publications

References 8 publications

Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors

Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Retinoblastoma

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