Application of fibrin glue to burns

Ihara, Nario; Suzuki, Koichiro; Tanaka, Hiroyuki; Nakamura, Yoshihiro; Tanabe, Jun; Fukuda, Atsuhiro; Fujii, Chiiho; Kohama, Akitsugu; Hamanaka, Takaomi; Tani, Tasaburo

doi:10.1016/0305-4179(84)90078-0

Cited by 24 publications

(4 citation statements)

References 8 publications

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“…In a rat model, a thin layer of fibrin glue was associated with greater adherence strength determined by the amount of force required to sheer the graft from the wound on postoperative days 1 to 3 33 . Several studies show that use of glue is associated with lower rates of hematoma or seroma 34,35 . From a patient perspective, glue is a useful aid for fixation in sensitive areas, reducing pain associated with staples or sutures 36 …”

Section: Resultsmentioning

confidence: 99%

“…Paw et al 38 identified 4 studies that assessed graft survival, with meta-analysis indicating no significant difference in graft take using fibrin glue compared with other methods. Non-English language articles and retrospective studies were excluded from this study, and reference lists were not assessed, resulting in the exclusion of relevant studies 34,43,44,47,49,50 . A systematic review by Miller et al 37 identified 3 studies comparing fibrin glue with other techniques in the context of burns, finding no difference in graft take.…”

Section: Resultsmentioning

confidence: 99%

“…33 Several studies show that use of glue is associated with lower rates of hematoma or seroma. 34,35 From a patient perspective, glue is a useful aid for fixation in sensitive areas, reducing pain associated with staples or sutures. 36 Sixteen level I to III studies (Table 4) assessed graft secured with glue compared with traditional methods including 2 systematic reviews, 5 RCTs, 5 prospective cohort comparison studies, and 4 retrospective cohort comparison studies.…”

Section: Retrospective Cohort Comparison (Iii)mentioning

confidence: 99%

“…Non-English language articles and retrospective studies were excluded from this study, and reference lists were not assessed, resulting in the exclusion of relevant studies. 34,43,44,47,49,50 A systematic review by Miller et al 37 identified 3 studies comparing fibrin glue with other techniques in the context of burns, finding no difference in graft take. The search terms were not defined, and exclusion criteria were not provided.…”

Section: Retrospective Cohort Comparison (Iii)mentioning

confidence: 99%

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Safeguarding Skin Grafts

Patel

Asher²,

Bystrzonowski³

et al. 2021

Ann Plast Surg

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Background Effective skin graft fixation is vital in preventing sheering forces, seroma, and hematoma from compromising graft take. Yet, selecting the ideal technique for securing skin grafts remains a contentious subject, with significant variation in practice existing between surgeons. There is, therefore, benefit to be derived from assessing the literature for evidence-based recommendations to guide the decision-making process. Methods A search of Medline and Embase was performed using appropriate key terms, yielding 419 articles. Reference lists were analyzed. Inclusion and exclusion criteria were composed. Level I to III studies, as defined by the Centre for Evidence-Based Medicine, that compared skin graft fixation methods were analyzed. Rayyan QCRI was used for abstract and title screening. After full text screening, 41 studies were included for qualitative analysis. All included randomized control trials (RCTs) were assessed for risk of bias using the Cochrane Risk-of-Bias 2 (ROB2) tool. Results We identified 4 groups of fixation technique: “tie-over bolster” (TOB), “no TOB,” “adhesive glues,” and “negative pressure wound therapy” (NPWT). Twelve studies compared TOB with no TOB, with no difference in graft take demonstrated. Sixteen studies compared adhesive glues with traditional methods, with no difference in graft take demonstrated. Thirteen studies compared NPWT with traditional methods, with enhanced graft take demonstrated. Risk of bias was deemed low in 1 of 13 RCTs. Conclusions Based on the current evidence, only NPWT is associated with enhanced graft take. However, there is a scarcity of robust level I evidence comparing different fixation techniques, meaning that strong recommendations cannot be made. We propose examples of hypothesis-driven RCTs, in predetermined clinical settings, based on the theoretical benefits of the techniques that would add value to clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Retrospective Cohort Comparison (Iii)mentioning

confidence: 99%

Section: Retrospective Cohort Comparison (Iii)mentioning

confidence: 99%

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Safeguarding Skin Grafts

Patel

Asher²,

Bystrzonowski³

et al. 2021

Ann Plast Surg

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Seroma Prevention Using Fibrin Glue in a Rat Mastectomy Model

Lindsey

Masterson²,

Spotnitz³

et al. 1990

Arch Surg

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Decreased Wound Contraction With Fibrin Glue—Treated Skin Grafts

et al. 1992

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Skin grafts can be used effectively to inhibit wound contraction. A critical element of this inhibition is the adherence of the graft to the wound bed. Fibrin glue has been shown to increase the adherence of skin grafts to wound beds. We therefore devised an experiment to determine the effect of fibrin glue on skin graft inhibition of wound contraction. Two 2.5 x 2.5-cm full-thickness defects were created on the dorsa of 15 Sprague-Dawley rats. Thirty partial-thickness grafts were harvested from isogeneric donor animals using a brown dermatome. Prior to grafting, one full-thickness defect, each animal received 0.2 mL of fibrin glue (Immuno AG, Vienna, Austria). The adjacent wound served as the control and received 0.2 mL of normal saline. Grafts were applied, sutured, and protected with an occlusive dressing. The size of graft sites treated with fibrin glue or normal saline was determined at the time of graft application and thereafter at 3-day intervals for 21 days using standardized photographic techniques. The percentage of change from initial wound size at each point was recorded for each group. Graft sites treated with fibrin glue contracted less than the controls from the ninth postgraft day to the completion of the study. The mechanism by which fibrin glue inhibits wound contraction may be related to increased adherence of grafts to the underlying wound bed. As an adjunct in skin grafting, fibrin glue may offer certain advantages that are not achieved by suturing alone.

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Application of fibrin glue to burns

Cited by 24 publications

References 8 publications

Safeguarding Skin Grafts

Safeguarding Skin Grafts

Seroma Prevention Using Fibrin Glue in a Rat Mastectomy Model

Decreased Wound Contraction With Fibrin Glue—Treated Skin Grafts

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