Application of Fecal Transplantation in the Treatment of No-Clostridia Antibiotic-Associated Colitis

Zakharenko, A. A.; Suvorov, A. N.; Shfyk, I. V.; Trushin, Anton; Ten, O. A.; Смирнов, А. А.; Belyaev, M. A.; Blinov, E. V.; Natha, A. S.; Bagnenko, S. F.

doi:10.33878/2073-7556-2017-0-2-75-79

Cited by 2 publications

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References 3 publications

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“…К настоящему времени в Российской Федерации опубликован ряд сообщений об успешных клинических случаях ТФМ [42][43][44][45][46][47][48]. Первые исследования ТФМ в России при болезни Крона, язвенном колите, ассоциированном с C. diffi cile, и функциональных заболеваниях кишечника показали ее значительный терапевтический эффект и перспективность для дальнейших научных исследований [16].…”

Section: тфм в российской федерацииunclassified

Russian experience in fecal microbiota transplantation

Власов

Морозов

2023

jour

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This study aims to give an analytical assessment of transplantation of fecal material in Russia. There was conducted a systematic review of Fecal Microbiota Transportation (FMT) publications over the past 10 years, studied the FMT experience of Russian research centers, and made a legal assessment of the efficacy and safety of this method of treatment. A conclusion was made about favorable conditions for the development of unique methods for correcting the intestinal microbiota by transplanting fecal material in clinical medicine and creating banks of donor material.

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Section: тфм в российской федерацииunclassified

Russian experience in fecal microbiota transplantation

Власов

Морозов

2023

jour

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Fecal microbiota transplantation for graft-versus-host disease in children and adults: methods, clinical effects, safety

Goloshchapov

Чухловин

Bakin

et al. 2020

Terapevticheskii arkhiv

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Aim.Was to evaluate clinical efficacy, adverse events and changes in the gut microbiome after fecal microbiota transplantation (FMT) in patients with gastrointestinal (GI) form of graft-versus-host disease (GVHD). Materials and methods.The prospective single-center study in R.M. Gorbacheva institute included 27 patients with GI GVHD after allogeneic stem cell transplantation. 19 patients received FMT, 8 patients received placebo. Clinical scales for GI autoimmune diseases were used to evaluate response. Microbiome alterations were assessed with multiplex PCR. Results.After FMT higher overall bacterial mass (р=0.00088), higher bacterial numbers ofBifidobacteriumspp. (р=0.021),Escherichia coli(р=0.049) andBacteroides fragilisgr. (р=0.000043) compared to placebo group. Also higher bacterial mass was observed in patients with clinical response (р=0.0057). The bacterial mass after procedure in non-responders was compared to the placebo group (р=0.31). Partial response of GVHD was achieved faster in the FMT group compared to placebo (median 4 days vs 48 days,p=0.014). Complete response was observed in 8 (42%), 14 (74%) and 16 (84%) at 30, 60 and 90 days respectively, while in the placebo group only 0%, 1 (13%) and 4 (50%) achieved complete response at the same time points. The incidence and severity of adverse events was comparable between FMT and the placebo group. Conclusion.FMT in patients with refractory GI GVHD was associated with favorable clinical outcomes and recovery in certain marker bacterial populations. Multiplex PCR can be used to assess an engraftment of a donor microbiota. FMT in GI GVHD was not associated with life-threatening adverse events, but further studies are required to validate clinical efficacy.

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Application of Fecal Transplantation in the Treatment of No-Clostridia Antibiotic-Associated Colitis

Abstract: This observation from practice shows modern possibilities of diagnostics and treatment of antibiotic associated gut infection in patient with cancer.

Cited by 2 publications

References 3 publications

Russian experience in fecal microbiota transplantation

Russian experience in fecal microbiota transplantation

Fecal microbiota transplantation for graft-versus-host disease in children and adults: methods, clinical effects, safety

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