Oxytetracycline hydrochloride, a long-standing pollutant in marine aquaculture wastewater (Lang et al., 2020), has been widely used in the advancement of fishery production and curing of animal disease. OTC-HCl could destroy the ecological balance, serious environmental pollution due to its direct discharge. Hence, it is important to remove the OTC-HCl from marine aquaculture wastewater. Various methods including air flotation (Wang et al., 2020b), adsorption (Arabkhani et al., 2020), incineration (Li et al., 2020, general chemical oxidation (Elkacmi & Bennajah, 2019), iron carbon micro electrolysis (Zhuang et al., 2019) and photocatalysis (Kumar et al., 2020) have been used to remove the OTC-HCl from the marine aquaculture wastewater. Among these methods, photocatalysis was widely used due to its environmental protection and efficient function (Sivaprakash et al., 2021). The ZnO has a function in photocatalysis.However, the photocatalytic capacity of the ZnO is low under visible light due to its huge band gap (3.2 eV) (Ansari et al., 2013). The ZnFe 2 O 4 is a kind of semiconductors with a narrow band gap (1.9 eV) (Li et al., 2000).And, it has high visible light utilization (Cheng et al., 2012). However, due to the narrow band gap of ZnFe 2 O 4 , photo-generated electrons and photo-generated holes generated in the ZnFe 2 O 4 are easy to recombine.To overcome this defect, a method is combining ZnFe 2 O 4 with ZnO, to design composite photocatalysts. Because a heterostructure is formed at the junction where ZnO and ZnFe 2 O 4 are in close contact, it can effectively inhibit the recombination of electron-hole pairs in ZnFe 2 O 4 /ZnO and improve the utilization of visible light. As a result, the photocatalytic efficiency of the composite photocatalyst is improved. To apply photocatalytic technology in seawater environment, Zn 0.75 Mn 0.75 Fe 1.5 O 4 /ZnFe 2 O 4 / ZnO composites has passed the first test as photocatalysts. The effect of Zn 0.75 Mn 0.75 Fe 1.5 O 4 makes the ZnFe 2 O 4 /ZnO photocatalyst more dispersed, which increases the specific surface area of the photocatalyst and increases the effective contact between the catalyst and the pollutant (Tian et al., 2008). Thus, the morphology structure of Zn 0.75 Mn 0.75 Fe 1.5 O 4 / ZnFe 2 O 4 /ZnO is conducive to improve the photocatalytic activity.