Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

Humphrey, Cara E.; Ahmed, Marwa F.; Ghanem, Ashraf; Turner, Nicholas J.

doi:10.1002/9783527650880.ch4

Cited by 3 publications

(2 citation statements)

References 97 publications

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“…133,134 Dynamic kinetic enzymatic resolution techniques can be found in literature and extensively investigated under resolution techniques title. 54,135,136 Photon inducible enzyme research has been observed as a new area because of the on-off concept of photo enzymes. 137,138 Biocatalysts are environmentally friendly, inexpensive, and sustainable and have high enantioselectivity.…”

Section: Enzymatic Catalysismentioning

confidence: 99%

Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods

2022

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The chirality of molecules is a concept that explains the interactions in nature. We may observe the same formula but different organizations revolving around the chiral center. Since Pasteur's meticulous observation of sodium ammonium tartrate crystals' structure, scientists have discovered many features of chiral molecules. The number of newly approved single enantiomeric drugs increases every year and takes place in the market. Thus, separation or resolution methods of racemic mixtures are of continued importance in the efficacy of drugs, installation of affordable production processes, and convenient synthetic chemistry practice. This article presents the asymmetric synthesis approaches and the classification of direct resolution methods of chiral molecules.

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Section: Enzymatic Catalysismentioning

confidence: 99%

Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods

2022

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“…The difference in the free energy between these transition states (ΔΔ G ‡ ) dictates the difference in rate constants ( k ) for the reaction of each enantiomer, allowing their discrimination and determination of the efficiency of the KR using the selectivity factor ( s ) values. 4 The catalytic KR can be divided into enzymatic, 5 which has long been a popular strategy, and non-enzymatic processes, 6 which include both metal catalysis 7 and organocatalysis. 8…”

Section: Introductionmentioning

confidence: 99%

Intramolecular hydrogen bond activation for kinetic resolution of furanone derivatives by an organocatalyzed [3 + 2] asymmetric cycloaddition

Valle-Amores,

Feberero,

Martin-Somer

et al. 2024

Org. Chem. Front.

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Deracemisation Processes Employing Organocatalysis and Enzyme Catalysis

et al. 2020

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Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can be converted to the other through a deracemisation procedure, that can be achieved by different mechanisms based on stereoinversion or enantioconvergence, often involving two‐opposite half reactions, with at least one of the reactions being enantioselective enough to finally obtain an enantioenriched chiral compound. The focus of this comprehensive review is on the application of deracemisation procedures in the present century in order to obtain optically active valuable compounds when employing non‐metallic catalysts. Thus, the review will mainly focus on the use of different enzymatic preparations (purified enzymes, cell‐free extracts or whole cell systems) and organocatalysts for the deracemisation of racemic mixtures.

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Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

Cited by 3 publications

References 97 publications

Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods

Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods

Intramolecular hydrogen bond activation for kinetic resolution of furanone derivatives by an organocatalyzed [3 + 2] asymmetric cycloaddition

Deracemisation Processes Employing Organocatalysis and Enzyme Catalysis

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