Application of Engineered Viral Nanoparticles in Materials and Medicine

Glidden, Michael D.; Edelbrock, John F.; Wen, Amy M.; Shukla, Sourabh; Ma, Yingfang; French, Roger H.; Pokorski, Jonathan K.; Steinmetz, Nicole F.

doi:10.1002/9783527683451.ch18

Cited by 3 publications

(2 citation statements)

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“…Viruses are nanocontainers that self‐assemble through electrostatic, ionic, and hydrophobic interactions between proteins of the capsid and between the genome and the capsid (Chevreuil et al, ). Physicochemical interactions are fundamental variables that can control loading efficiency, affinity, and release rates of cargos (Glidden et al, ). Alteration of the PVNPs in response to environmental conditions can help load and release artificial cargos as desired (Cheng et al, ; Pokorski & Steinmetz, ; Thong, Biabanikhankahdani, Ho, Alitheen, & Tan, ).…”

Section: Loading Of Cargo In Plant Virus Nanoparticlesmentioning

confidence: 99%

Plant viral nanoparticles for packaging and in vivo delivery of bioactive cargos

Shahgolzari

Pazhouhandeh

Milani

et al. 2020

WIREs Nanomed Nanobiotechnol

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Nanoparticles have unique capabilities and considerable promise for many different biological uses. One capability is delivering bioactive cargos to specific cells, tissues, or organisms. Depending on the task, there are multiple variables to consider including nanoparticle selection, targeting strategies, and incorporating cargo so it can be delivered in a biologically active form. One nanoparticle option, genetically controlled plant viral nanoparticles (PVNPs), is highly uniform within a given virus but quite variable between viruses with a broad range of useful properties. PVNPs are flexible and versatile tools for incorporating and delivering a wide range of small or large molecule cargos. Furthermore, PVNPs can be modified to create nanostructures that can solve problems in medical, environmental, and basic research. This review discusses the currently available techniques for delivering bioactive cargos with PVNPs and potential cargos that can be delivered with these strategies. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures

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Section: Loading Of Cargo In Plant Virus Nanoparticlesmentioning

confidence: 99%

Plant viral nanoparticles for packaging and in vivo delivery of bioactive cargos

Shahgolzari

Pazhouhandeh

Milani

et al. 2020

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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“…RNA-based therapeutics may also have fewer side effects since these molecules are naturally expressed in target organs and therefore should be tolerated by normal cells. There has been much work done on the use of plant viruses, like cowpea mosaic virus or tobacco mosaic virus, or synthetic lipid nanoparticles (LNPs) as extracellular vesicle-like therapeutic-agent delivery vehicles [61,[105][106][107][108][109]. Using LNPs as regulatory-RNA cargo delivery vehicles provides excellent therapeutic advantages; the LNP envelope can be modified to promote organ specific targeting, the RNA cargo is protected from host degradation enzymes and the circulation half-life of the therapeutic agent is increased, resulting in an increase in therapeutic efficiency [110,111].…”

Section: Expert Opinionmentioning

confidence: 99%

Novel therapeutic targets for cancer metastasis

Stoletov

Beatty

Lewis

2020

Expert Review of Anticancer Therapy

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Introduction: Metastatic cancers are extremely difficult to treat, and account for the vast majority of cancer-related deaths. The dissemination of tumor cells to distant sites is highly dynamic, asynchronous, and involves both tumor and host intrinsic factors. Effective therapeutic targets to block metastasis will need to disrupt key pathways that are required for multiple stages of metastasis. Areas covered: This review discusses the heterogeneity of cancers and metastasis, with an emphasis on motility as a key driver trait of metastasis. Recent metastatic cancer studies that identified either host or cancer cell intrinsic factors important for metastasis, using single gene-deficient animal models or 3D intravital imaging of avian embryo models, are also discussed. Potential metastatic blocking targets are listed as they relate to metastatic cancer therapy. Expert opinion: The development of metastatic disease is a complex interplay of genetic and epigenetic factors from the host and cancer cells acting in a patient-specific manner. Inhibiting key driver traits of metastasis should yield survival benefit at any stage of the disease, and we look forward to the next generation of personalized medicines for cancer therapy that target cancer cell motility for increased therapeutic efficacy. ARTICLE HISTORY

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