Application of Electrochemical Techniques to the Solution of Problems in Medicine

Surface characterization of functional poly(diacetylene) and poly(butadiene) mono- and multilayers

“…Thus, it is impossible to determine the surface potential itself but only the so-called zeta potential ~, at the shear plane [20][21][22][23] between the layer of adsorbed ions and nonbound ions. Nevertheless, give useful information related to surface charge densities and the kind of charge on the surfaces, which may be useful parameters for estimating the biocompatibility of synthetic materials [22]. Usually zeta potential data are calculated from streaming potential values, which are obtained when an electrolyte solution forced by a pressure difference AP flows through a thin capillary or flat plate cell provided with two electrodes.…”

“…The major advantage of this method is that the flat surfaces permit the application of other surface characterization techniques. With the flat plate cell zeta potentials can be calculated from [19][20][21][22] In addition, the surface charge density at the shear plane can be obtained from the relation…”

“…In the present work we were interested in the effect of charge of polymer monolayers on the zeta potential. It has been shown [21][22][23][24] that the addition of a small amount of charge to hydrophilic methacrylates did tend to increase absolute streaming potential values with increasing amounts of charge addition.…”

Fibrinogen adsorption onto 316L stainless steel under polarized conditions

“…The second reason for studying electrified biomedical alloys is that we know, from the work of Sawyer, that we may retard thrombotic events with the application of cathodic voltage 16. From the 1960s through the 1980s, Sawyer and coworkers performed a series of experiments studying the effect of electrode voltage on coagulation and other protein‐surface interactions 16–31. They observed increased macro‐scale coagulation at more anodic voltages with inhibited clotting at more cathodic voltages.…”

“…16 From the 1960s through the 1980s, Sawyer and coworkers performed a series of experiments studying the effect of electrode voltage on coagulation and other protein-surface interactions. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] They observed increased macro-scale coagulation at more anodic voltages with inhibited clotting at more cathodic voltages. Stoner and Walker theorized that the anodic effect was due to the electro-polymerization of the Fb into fibrin matrices.…”