Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins

Ali, Asghar; Shahid, Najia; Musharraf, Syed Ghulam

doi:10.1039/c6ra27156a

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2021

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“…Dopants also sometimes play a very important role in ionization processes (Ali et al, 2017). In case of the previously mentioned GALDI-MS, sodium and potassium cations found in pencil lead take part in the formation of adducts of molecules.…”

Section: Matrixesmentioning

confidence: 99%

Recent Advances in Combinations of TLC With MALDI and Other Desorption/Ionization Mass-Spectrometry Techniques

2021

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The combination of planar chromatography with desorption/ionization mass-spectrometry (MS) techniques provides chemists with unique tools for fast and simple separation of mixtures followed by the detection of analytes by the most powerful analytical method. Since its introduction in the early 1990s, thin-layer chromatography (TLC)/matrix-assisted mass spectrometry (MALDI) has been used for the analysis of a wide range of analytes, including natural and synthetic organic compounds. Nowadays, new desorption/ionization approaches have been developed and applied in conjunction with planar chromatography competing with MALDI. This review covers recent developments in the combination of TLC with various desorption/ionization MS methods which were made in recent several years.

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Section: Matrixesmentioning

confidence: 99%

Recent Advances in Combinations of TLC With MALDI and Other Desorption/Ionization Mass-Spectrometry Techniques

2021

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Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins

Abstract: Dyes can significantly influence the ionization of proteins, when used as dopants in conventional matrices used for Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS).

Cited by 1 publication

References 37 publications

Recent Advances in Combinations of TLC With MALDI and Other Desorption/Ionization Mass-Spectrometry Techniques

Recent Advances in Combinations of TLC With MALDI and Other Desorption/Ionization Mass-Spectrometry Techniques

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