Application of DoE approach in the development of mini-capsules, based on biopolymers and manuka honey polar fraction, as powder formulation for the treatment of skin ulcers

Tenci, Marika; Rossi, Silvia; Sandri, Giuseppina; Mentori, Irene; Boselli, Cinzia; Cornaglia, Antonia Icaro; Daglia, Maria; Marchese, Anna; Caramella, Carla; Ferrari, Franca

doi:10.1016/j.ijpharm.2016.10.050

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…The DoE approach is widely applied to optimize the composition of mixtures, i.e., excipients, in pharmaceutical products manufacturing [48,49]. For a three-component mixture, the experimental space is a triangular plane and three different experimental designs with three, six, seven, or ten points can be selected [48,49,50,51]. The goal of a mixture design is to determine an optimum blend of components (factors) inside the experimental region, characterized by the desired values of each response variable considered [52].…”

Section: Methodsmentioning

confidence: 99%

An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Aristotelia Chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent

et al. 2019

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The aim of the present work was the development of an innovative in situ gelling system, to be applied on the mucosa of the distal colon via rectal route. The system consisted of three polymers having different functions: gellan (GG), able to jellify in presence of ions; methylcellulose (MC), a thermosensitive polymer with a gelation temperature close to 50 °C; and hydroxypropylcellulose (HPC), a mucoadhesive polymer. The three polymers were able to act synergistically, increasing the permanence of the vehicle on the mucosa and forming a protective gel layer. A DoE approach, “simplex centroid mixture design,” was used to identify the optimal quantitative composition of the vehicle. The response variables considered were: vehicle viscosity at room temperature; increase in vehicle viscosity on increasing temperature (from room to physiological value) and upon dilution with simulated colonic fluid (SCF); and viscoelastic behavior, thixotropic area, and mucoadhesion properties of the gel formed at 37 °C upon dilution in SCF. The optimized vehicle was loaded with maqui berry extract (MBE), known for its antioxidant and anti-inflammatory properties. MBE loading (0.5% w/w) into the vehicle improved rheological and mucoadhesive properties of the formulation. Both MBE and the optimized vehicle were not cytotoxic towards human fibroblasts and Caco-2 cells. Moreover, the optimized vehicle did not affect MBE antioxidant properties.

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Section: Methodsmentioning

confidence: 99%

An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Aristotelia Chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent

et al. 2019

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“…In another recent example of CHS polymer blends, CHSG/PEC/HA mini-capsules were prepared by inverse ionotropic gelation in presence of calcium chloride and subsequently freeze-dried to obtain a powder formulation for the delivery of MH bioactive components in the treatment of chronic skin ulcers [ 136 ]. Optimization of unloaded mini-capsules was performed using a DoE approach.…”

Section: Polysaccharidesmentioning

confidence: 99%

Biomaterials for Soft Tissue Repair and Regeneration: A Focus on Italian Research in the Field

et al. 2021

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Tissue repair and regeneration is an interdisciplinary field focusing on developing bioactive substitutes aimed at restoring pristine functions of damaged, diseased tissues. Biomaterials, intended as those materials compatible with living tissues after in vivo administration, play a pivotal role in this area and they have been successfully studied and developed for several years. Namely, the researches focus on improving bio-inert biomaterials that well integrate in living tissues with no or minimal tissue response, or bioactive materials that influence biological response, stimulating new tissue re-growth. This review aims to gather and introduce, in the context of Italian scientific community, cutting-edge advancements in biomaterial science applied to tissue repair and regeneration. After introducing tissue repair and regeneration, the review focuses on biodegradable and biocompatible biomaterials such as collagen, polysaccharides, silk proteins, polyesters and their derivatives, characterized by the most promising outputs in biomedical science. Attention is pointed out also to those biomaterials exerting peculiar activities, e.g., antibacterial. The regulatory frame applied to pre-clinical and early clinical studies is also outlined by distinguishing between Advanced Therapy Medicinal Products and Medical Devices.

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“…When loaded into a chitosan-pectin matrix, this fraction improved wound healing in a rat model (Tenci et al, 2016). Subsequent studies developed minicapsule formulations of this fraction that improved its effectiveness in wound healing in an animal model in vivo by stimulating tissue growth, minimizing scar formation (Tenci et al, 2017). Rathinamoorthy and Sasikala (2019), developed a bioactive dressing based on chitosan and manuka honey for wound healing.…”

Section: Biological Activity Of Monofloral Honeysmentioning

confidence: 99%

Bioactive compounds in Apis mellifera monofloral honeys

Viteri

Zacconi

Montenegro

et al. 2021

Journal of Food Science

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Honey is a natural product with a sweet flavor. Honey is made by the honeybee (Apis mellifera L.) from the nectar of flowers or other plant secretions that are collected near the hive. These products are mixed with bee saliva and stored. Several studies have demonstrated that honey exhibits antioxidant, antimicrobial, nematicidal, antifungal, anticancer, and anti‐inflammatory activities. These properties are influenced by the plants from which the secretions are harvested, from the naturally occurring compounds present in the nectar. Studies of the properties and applications of honey have distinguished honey from other natural products due to the presence of certain compounds and due its bioactive properties. The focus of this review is to discuss the identified and isolated compounds from monofloral honey produced by A. mellifera, with specific emphasis on antioxidant and antimicrobial properties of honey and its therapeutic health benefits.

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Application of DoE approach in the development of mini-capsules, based on biopolymers and manuka honey polar fraction, as powder formulation for the treatment of skin ulcers

Cited by 10 publications

References 28 publications

An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Aristotelia Chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent

An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Aristotelia Chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent

Biomaterials for Soft Tissue Repair and Regeneration: A Focus on Italian Research in the Field

Bioactive compounds in Apis mellifera monofloral honeys

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