Application of direct transcranial current as non-invasive therapy in eating disorders: an intervention proposal

Mendoza, Ana Rosario Pellón; Castaño-Castaño, Sergio

doi:10.33000/mlspr.v3i1.468

Cited by 1 publication

(5 citation statements)

References 39 publications

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“…The EEG study by Grunwald et al [73] demonstrated hyperactivation in the RH of individuals with AN. Similarly, the positron emission tomography (PET) study conducted by Galusca et al focused on serotonin activity around 5-HT1A receptors in people with AN, revealing an increased number of serotonergic junctions, particularly in the fronto-temporal regions of the RH [74,75].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…The pathogenesis of AN involves imbalances in serotonergic signaling in the ventral striatum, potentially related to the aversive aspects of the disorder [75,76]. Another theory proposes disruptions in reward pathways, as alterations in the dopamine system can affect reward circuitry, leading to anxiety and dysphoric moods [75,77]. Wagner et al [78] discovered a dopamine imbalance in the ventral striatum of AN patients, characterised by decreased neuronal activity and hyperexcitability of the caudate nucleus.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…Cathodal tDCS, but not anodal tDCS, led to increased extracellular dopamine levels in the rat striatum for over 400 min. These findings suggest that tDCS may directly or indirectly impact the dopaminergic system in the basal ganglia, potentially affecting certain pathophysiological mechanisms of AN, including mesocortical dopaminergic pathways and increased food intake [75]. However, it remains unclear whether a current of such intensity can effectively reach deeper brain structures in humans.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…Mesolimbic dopaminergic projections in the striatum play a crucial role in guiding eating behaviour by modulating appetitive motivational processes. It has been suggested that disturbances in dopaminergic reward pathways contribute to the pathogenesis of AN [75,81,82].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

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The Effect of Transcranial Direct Current Stimulation (tDCS) on Anorexia Nervosa: A Narrative Review

Chmiel,

Gladka,

Leszek

2023

Nutrients

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(1) Introduction: Anorexia nervosa (AN) is a severe, debilitating disease with high incidence and high mortality. The methods of treatment used so far are moderately effective. Evidence from neuroimaging studies helps to design modern methods of therapy. One of them is transcranial direct current stimulation (tDCS), a non-invasive brain neuromodulation technique. (2) Methods: The purpose of this narrative review is to bring together all studies investigating the use of tDCS in the treatment of AN and to evaluate its effect and efficiency. Searches were conducted in the Pubmed/Medline, Research Gate, and Cochrane databases. (3) Results: The literature search resulted in five articles. These studies provide preliminary evidence that tDCS has the potential to alter eating behaviour, body weight, and food intake. Additionally, tDCS reduced symptoms of depression. Throughout all trials, stimulation targeted the left dorsolateral prefrontal cortex (DLPFC). Although the number of studies included is limited, attempts were made to elucidate the potential mechanisms underlying tDCS action in individuals with AN. Recommendations for future tDCS research in AN were issued. (4) Conclusions: The included studies have shown that tDCS stimulation of the left DLPFC has a positive effect on AN clinical symptoms and may improve them, as measured by various assessment measures. It is important to conduct more in-depth research on the potential benefits of using tDCS for treating AN. This should entail well-designed studies incorporating advanced neuroimaging techniques, such as fMRI. The aim is to gain a better understanding of how tDCS works in AN.

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Section: Mechanisms Of Actionmentioning

confidence: 99%