Application of diffusion kurtosis imaging to odontogenic lesions: Analysis of the cystic component

Sakamoto, Junichiro; Kuribayashi, Ami; Kotaki, Shinya; Fujikura, Mamiko; Nakamura, Shin; Kurabayashi, Tohru

doi:10.1002/jmri.25307

Cited by 16 publications

(17 citation statements)

References 19 publications

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“…Also, DWI were obtained, which highlighted for the first time the importance of the apparent coefficient of diffusion (ADC) for a better mapping of these lesions. 13,19 Results obtained by Sumi et al 16 Accordingly, Srinivasan et al 17 presents, in the form of conventional MRI images, OKC and ameloblastomas respectively as cystic and mixed lesions, hence agreeing with previous research. 17,18 The T1 / T2 analysis for OKC is similar to research done by Minami et al 13 However, Minami et al 13 achieved better detailing of the images of ameloblastomas despite using conventional MRI images that may show overlapping.…”

Section: Conventional Mri With or Without Contrastsupporting

confidence: 81%

“…These similarities include: the description of the aspect of the pathology, the specific signal intensity for each lesion and the numerical ADC values. 13,[16][17][18][19] The protocols with conventional MR images with contrast application, studies have agreed with the presence of enhancement of the cystic walls for both lesions. Regarding the description of the lesions, OKC had different signal intensity patterns for T1 and T2, while images of ameloblastomas were described in hyposignal for T1 and hypersignal for T2.…”

Section: Discussionmentioning

confidence: 60%

“…For some examples of OKC and ameloblastomas, MRI employing DWI proved to be a useful tool for differential diagnosis between these lesions. 16,17,19 Studies of OKC and ameloblastoma using conventional MRI 13,18 using contrast (gadolinium) showed that the images produced with the use of contrast enhancement, especially of the walls of OKC and ameloblastomas, was presented as consistent. Accordingly, contrast enhancement was described as a factor for a proper differential diagnosis between the KOC and ameloblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the clinical manifestation, if the lesions display more specific radiographic features, such as the intraosseous septa of a multicystic ameloblastoma; the "radiologists as well as the surgeon will not find it difficult to identify them". 16 Sumi et al 16 [18][19][20][21][22] Srinivasan et al 17 have shown the utility of MRI images for the differential diagnosis among subtypes of unicystic ameloblastomas. Through the use of contrast techniques, ameloblastic lesions appear to be mixed (solid and cystic), being predominantly cystic in some cases and purely cystic in others.…”

Section: Methodsmentioning

confidence: 99%

“…When these ameloblastomas have cystic variants, keratocysts should be part of the differential diagnosis. 13,16,19 Probst et al 8 reported the challenge in past studies of differentiating OKC by MR imaging.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of MRI in the differential diagnosis of odontogenic keratocyst: literature review

et al. 2018

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According to the World Health Organization (WHO 2017), the odontogenic keratocyst (OKC) is classified as an odontogenic developmental cyst, with origins from the cellular remnants of the dental lamina. The characteristics of a high rate of cell proliferation, relapse and aggressive growth guide the choice of the type of surgical treatment for the lesion and, consequently, the prognosis. The use of Magnetic Resonance Imaging (MRI) for the differential diagnosis of odontogenic lesions does not replace anatomopathological examination, but the types of protocols already described illustrate the influence of these different protocols on the qualitative and quantitative description of keratocysts. We conclude that magnetic resonance imaging is valid as a tool to aid diagnosis of odontogenic lesions, especially for differential diagnosis studies between odontogenic keratocysts and ameloblastomas.

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Section: Conventional Mri With or Without Contrastsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Efficacy of MRI in the differential diagnosis of odontogenic keratocyst: literature review

et al. 2018

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Application of Diffusion Kurtosis Imaging and Dynamic Contrast‐Enhanced Magnetic Resonance Imaging in Differentiating Benign and Malignant Head and Neck Lesions

Cheng

Shao

Chen

et al. 2021

Magnetic Resonance Imaging

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Background: Preoperative differentiation of head and neck lesions is important for treatment plan selection. Purpose: To evaluate the diagnostic value of diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating benign from malignant head and neck lesions and subgroups, including lymphoma subgroup (LS), Warthin's tumor subgroup (WS), malignant tumor subgroup (excluding lymphoma) (MTS), and benign tumor subgroup (excluding Warthin's tumor) (BTS). Study Type: Retrospective. Population: Seventy-four patients with 79 head and neck lesions (44 benign, 35 malignant), divided into four subgroups: LS ( 14), WS (12), MTS (21), and BTS (32). Field Strength/Sequences: A 3.0 T, single-shot echo-planar sequence with 5 b-values for DKI and enhanced T1 highresolution isotropic volume excitation (eTHRIVE) sequence for DCE-MRI. Assessment: The mean diffusivity (MD) and mean kurtosis (MK) derived from DKI and the time-signal intensity curve (TIC), peak time (T peak ), and washout ratio (WR) based on DCE-MRI were measured. The diagnostic efficiencies of DKI and DCE-MRI, alone and in combination, were calculated and compared. The parameters mentioned above were compared between the four subgroups. Statistical Test: Mann-Whitney U test, chi-square test, receiver operating characteristic curve, Delong test, one-way analysis of variance test, and Kruskal-Wallis H test. A P value < 0.05 was considered statistically significant. Results: The combination of TIC and parameters of DKI and DCE-MRI for differentiating benign and malignant lesions with 94.94% accuracy is superior to DKI or DCE-MRI alone with approximately 75% accuracy. MD, MK, T peak , and WR showed significant differences among the four subgroups. The accuracy of MD and MK was 91.14% and 92.41% for differentiating BTS from the other three subgroups. WR achieved 100% accuracy for discriminating WS from LS or MTS. MD and MK both differentiated LS from MTS with 97.14% accuracy. Data Conclusion: A combination of DKI and DCE-MRI can effectively differentiate head and neck lesions with good accuracy.

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Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour

et al. 2018

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The latest (4th) edition of the World Health Organization (WHO) Classification of Head and Neck Tumours, published in January 2017, has reclassified keratocystic odontogenic tumour as odontogenic keratocyst. Therefore, odontogenic keratocysts (OKCs) are now considered benign cysts of odontogenic origin that account for about 10% of all odontogenic cysts. OKCs arise from the dental lamina and are characterised by a cystic space containing desquamated keratin with a uniform lining of parakeratinised squamous epithelium. The reported age distribution of OKCs is considerably wide, with a peak of incidence in the third decade of life and a slight male predominance. OKCs originate in tooth-bearing regions and the mandible is more often affected than the maxilla. In the mandible, the most common location is the posterior sextant, the angle or the ramus. Conversely, the anterior sextant and the third molar region are the most common sites of origin in the maxilla. OKCs are characterised by an aggressive behaviour with a relatively high recurrence rate, particularly when OKCs are associated with syndromes. Multiple OKCs are typically associated with the nevoid basal cell carcinoma syndrome (NBCCS), an autosomal dominant multisystemic disease. Radiological imaging, mainly computed tomography (CT) and, in selected cases, magnetic resonance imaging (MRI), plays an important role in the diagnosis and management of OKCs. Therefore, the main purpose of this pictorial review is to present the imaging appearance of OKCs underlining the specific findings of different imaging modalities and to provide key radiologic features helping the differential diagnoses from other cystic and neoplastic lesions of odontogenic origin.Key Points• Panoramic radiography is helpful in the preliminary assessment of OKCs.• CT is considered the tool of choice in the evaluation of OKCs.• MRI with DWI or DKI can help differentiate OKCs from other odontogenic lesions.• Ameloblastoma, dentigerous and radicular cysts should be considered in the differential diagnosis.• The presence of multiple OKCs is one of the major criteria for the diagnosis of NBCCS.

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Application of diffusion kurtosis imaging to odontogenic lesions: Analysis of the cystic component

Abstract: Use of DKI may be feasible for common odontogenic lesions. A combination of DKI parameters can be expected to increase the accuracy of its diagnostic ability compared with ADC. J. Magn. Reson. Imaging 2016;44:1565-1571.

Cited by 16 publications

References 19 publications

Efficacy of MRI in the differential diagnosis of odontogenic keratocyst: literature review

Efficacy of MRI in the differential diagnosis of odontogenic keratocyst: literature review

Application of Diffusion Kurtosis Imaging and Dynamic Contrast‐Enhanced Magnetic Resonance Imaging in Differentiating Benign and Malignant Head and Neck Lesions

Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour

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