Application of dense gas techniques for the production of fine particles

Single-Step Preparation and Deagglomeration of Itraconazole Microflakes by Supercritical Antisolvent Method for Dissolution Enhancement

“…5 The use of supercritical fluids for the production of microparticles/ nanoparticles is of great interest in recent years due to advantages such as low or no residual solvent in the process, a narrow particle size distribution, effective deagglomeration of the cohesive drug particles, and increased dissolution rate profiles. 2,14,[25][26][27][28]32 Among different methods using supercritical fluids, precipitation using supercritical carbon dioxide (CO 2 ) as an antisolvent is well known and has been used to micronize several kinds of compounds. CO 2 is an ideal supercritical fluid because of its low critical temperature (31.18…”

Increasing the Dissolution Rate of Itraconazole Processed by Gas Antisolvent Techniques using Polyethylene Glycol as a Carrier

“…Conventional techniques for micronization and coprecipitation of pharmaceuticals are often not ideal for use with many pharmaceuticals since the properties of the drug can be altered by thermal and mechanical stress. Moreover, conventional techniques often result in high residual solvent content, requiring further purification, and material with a broad and/ or irregular particle size distribution (21). The use of dense gas technology for the precipitation of pharmaceuticals has been the topic of a number of recent studies.…”

“…The use of dense gas technology for the precipitation of pharmaceuticals has been the topic of a number of recent studies. The technology has been used for the micronization of pharmaceuticals with low or no residual solvent, a narrow particle size distribution and, in the case of oral drugs, with increased dissolution rate profiles (21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

“…Several dense gas techniques have been developed for drug formulation, crystallisation and micronization. These include gas antisolvent techniques, depressurization of an expanded liquid organic solvent (DELOS), carbon dioxide assisted nebulization with a bubble dryer (CAN-BD), supercritical-assisted atomization (SAA), rapid expansion of supercritical solutions (RESS) and particles from gas-saturated solutions (PGSS) (21). In this study two gas antisolvent techniques, namely the gas antisolvent (GAS) process and aerosol solvent extraction system (ASES), were used to process itraconazole.…”

Micronization of Magnolia Bark Extract with Enhanced Dissolution Behavior by Rapid Expansion of Supercritical Solution

“…Accurately weighted samples containing the equivalent of 100 mg of the amount of magnolol and honokiol were spread in the dissolution medium. Then, 5 ml dissolution medium was piped at certain time (5,10,20,30,45, 60, 90 min) and passed through a 0.45 mm membrane filter. The withdrawn dissolution medium was replaced with equal quantities of fresh dissolution medium to maintain a constant volume.…”