Application of deep eutectic solvents (DESs) as trace level drug extractants and drug solubility enhancers: State-of-the-art, prospects and challenges

WeidongLu,; Chen, Huiqin

doi:10.1016/j.molliq.2021.118105

Cited by 29 publications

(11 citation statements)

References 108 publications

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“…Aggregation behavior of amphiphiles is majorly governed by their structure, their concentration, and the physicochemical properties of the surrounding milieu, such as surface tension, conductivity, viscosity, refractive index, acidity, polarity, and thermal properties. Apart from offering an understanding of the solute–solvent interactions, studies of the aggregation process within novel solvents also aid in advancing their applications in different fields, such as template-assisted synthesis of porous materials and nanoparticles, extraction, flow-field regulators, chemical analyses, nanoreactors for enzymatic reactions, emulsification, and drug delivery systems, to name a few. − Several molecular solvents and ionic liquids have been scouted for their ability to promote amphiphile self-assembly. − The pursuit for novel solvent systems is imperative since the synthesis and investigation of new solubilizing media sustaining self-assembly will enhance the understanding of solvent properties that stimulate the self-aggregation phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Constituent- and Composition-Dependent Surfactant Aggregation in (Lanthanide Salt + Urea) Deep Eutectic Solvents

2023

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Due to the ease of tailoring the physicochemical properties by simply changing a constituent or composition, deep eutectic solvents (DESs) possess widely varying capabilities for surfactant self-assembly that could depend on the surfactant headgroup charge. The self-aggregation process of three surfactants, sodium dodecylsulfate (SDS), cetyltrimethylammonium bromide (CTAB), and Triton X-100 (TX-100), dissolved in DESs composed of a lanthanide salt (Ln) and urea (U) is investigated. The role of the identity of the metal salt is assessed by using [La(NO 3 ) 3 •6H 2 O] (La) and [Ce(NO 3 ) 3 •6H 2 O] (Ce) and that of the composition is deciphered by systematically changing the mole ratio of the metal salt and urea in (La/U) DESs. The response to a fluorescence probe pyrene-1-carboxaldehyde along with electrical conductance and surface tension measurements is used to obtain the critical aggregation concentration (CAC). While the CACs in 1:3.5 (Ln/U) for SDS are significantly lower than that in water, the values are marginally higher for CTAB and TX-100. The CACs for all three surfactants are similar in 1:3.5 (La/U) and (Ce/U) DESs, implying that the identity of the metal in the salt is not so important. Increasing the urea composition in (La/U) DESs results in increased CAC for SDS and CTAB; however, a minimal decrease in CAC is observed for TX-100. From the temperature dependence of CAC, thermodynamic parameters, ΔG agg 0 , ΔH agg 0 , and ΔS agg 0 , of the surfactant self-aggregation process are estimated. These parameters reveal that while at a lower urea content, the SDS/CTAB self-assembly process is enthalpically driven, it becomes entropically favored at higher urea concentrations. The TX-100 self-aggregation in these DESs is found to be strongly enthalpically favored and entropically un-favored. These parameters are explained as a combination of passage of the solvophobic surfactant chain from the bulk DES to the aggregate pseudo-phase and differential orientation/organization of DES constituents around surfactant monomers and/or aggregates.

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Section: Introductionmentioning

confidence: 99%

Constituent- and Composition-Dependent Surfactant Aggregation in (Lanthanide Salt + Urea) Deep Eutectic Solvents

2023

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“…6,7 Knowledge regarding these properties can help design the DES-based solvent for targeted applications. 7,8 The hydrogen-bonding ability makes them suitable candidates for separation and purification. The sparingly soluble drug molecules were solubilized utilizing DES.…”

Section: Introductionmentioning

confidence: 99%

“…The DES-based liquid−liquid microextraction process was also thus employed for isolation of important analytes. 7,8 The antibiotics most commonly used as veterinary and human medicines were extracted using DES. 7,8 Knowledge regarding the mechanism involved in drug solubilization or extraction by DES is still being evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…The same can also be prepared by physical agitation (such as grinding) of the required components in a pestle to obtain a clear liquid . Once prepared, the DES were studied to obtain data on their physicochemical properties such as density, viscosity, surface tension, hygroscopicity, and ionic conductivity. , Knowledge regarding these properties can help design the DES-based solvent for targeted applications. , The hydrogen-bonding ability makes them suitable candidates for separation and purification. The sparingly soluble drug molecules were solubilized utilizing DES.…”

Section: Introductionmentioning

confidence: 99%

“…The sparingly soluble drug molecules were solubilized utilizing DES. The DES-based liquid–liquid microextraction process was also thus employed for isolation of important analytes. , The antibiotics most commonly used as veterinary and human medicines were extracted using DES. , Knowledge regarding the mechanism involved in drug solubilization or extraction by DES is still being evaluated. Numerous reports are available on the extraction ability of DES; however, studies on the basic properties of DES that influence the extent of interactions between the analyte and DES still need to be conducted. − …”

Section: Introductionmentioning

confidence: 99%

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PEGylated Deep Eutectic Solvent–Caffeine Interactions in Aqueous Solutions Evaluated by Volumetric and Spectroscopic Studies

Singh,

Pattanvall,

Indoria

2023

J. Chem. Eng. Data

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Deep eutectic solvents (DES) can be prepared with ease by mixing a suitable combination of a hydrogen-bond acceptor (HBA) and a hydrogen-bond donor (HBD) using a molar ratio. The prepared DES can have various unexplored applications, which depend on their unique physicochemical properties. Among these applications, DES have been recently studied for drug delivery and drug solubilization. The possibility of having hydrogen-bonding and polar/nonpolar interactions with a drug molecule can help DES solubilize the sparingly soluble drug molecules. The nature of these interactions can be modulated by a change in temperature, concentration, or even by the presence of moisture. Interactions between DES and drug molecules mediated by water were studied by measuring the volumetric properties and UV− visible spectra of caffeine (CAF) in aqueous DES solutions as a function of concentration and temperature. PEG-400 and citric acid were mixed in an appropriate molar ratio for the preparation of PEGylated DES. The volumetric properties were studied by measuring the density and speed of sound at (293.15−318.15) K and 0.1 MPa. UV−visible studies were performed at 298.15, 308.15, and 318.15 K. Apparent molar volumes, infinite dilution partial molar volumes, and volumetric transfer parameters were evaluated and interpreted to explain the solute−solute, solute−solvent, and solute−cosolute interactions between CAF and DES in aqueous mixtures. The results suggest the presence of various interactions among the components of DES and CAF. Further, dimerization of CAF caused a decrease of absorbance with an increase in cosolute concentration.

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Physical–chemical and ecotoxic evaluation of different deep eutectic solvents for green analytical applications

Costa

França

Souza

et al. 2023

Environ Sci Pollut Res

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Application of deep eutectic solvents (DESs) as trace level drug extractants and drug solubility enhancers: State-of-the-art, prospects and challenges

Cited by 29 publications

References 108 publications

Constituent- and Composition-Dependent Surfactant Aggregation in (Lanthanide Salt + Urea) Deep Eutectic Solvents

Constituent- and Composition-Dependent Surfactant Aggregation in (Lanthanide Salt + Urea) Deep Eutectic Solvents

PEGylated Deep Eutectic Solvent–Caffeine Interactions in Aqueous Solutions Evaluated by Volumetric and Spectroscopic Studies

Physical–chemical and ecotoxic evaluation of different deep eutectic solvents for green analytical applications

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