This paper focuses on a comparative performance assessment between the two Multi-Input DC-DC converters, Boost and SEPIC (Single Ended Primary Inductor Conductor) that are widely used in different sectors of technologies. Most importantly, in the field of renewable energy, power electronics circuits like DC-DC converters are widely used because of the low voltage produced by renewable energy sources (RES), especially PV modules. Boost and SEPIC, both converters have the capability of boosting the low voltage to a higher voltage. Whereas the boost converter can only raise the voltage level, the SEPIC converter can step up and down the voltage in accordance with the switching circuit's duty cycle. In this literature, the SEPIC converter is run in boost mode to present a perfect comparison. Furthermore, the comparison is made between the modified SEPIC and Boost topologies where both of the converters are made to take input from more than one source. Primarily, the hybridization of solar modules and wind turbines are used as the input energy sources for the converters in this project. MATLAB/Simulink simulation tool is used for the comparative experiment, and constant irradiation level from the sun and wind speed is maintained throughout the simulation phase for both of the converter topologies. Validation of the comparative assessment is substantiated by the findings from the Simulink result. With less initial ripple, the Boost converter shows a promising outcome over the SEPIC converter topology and also it delivers higher output voltage.