Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro.

Kanke, Motoko; Tanabe, Emi; Katayama, Hirokazu; Koda, Yoko; Yoshitomi, Hironori

doi:10.1248/bpb.18.1154

Cited by 49 publications

(20 citation statements)

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“…In recent years, this polysaccharide attracted growing attention in biomedical and pharmaceutical applications [20]. Encapsulation of theophylline, salbutamol sulfate, prednisolone, indomethacin, doxorubicin and epirubicin with β-glucan has been shown to improve the pharmacokinetics of drugs [21][22][23][24]. Moreover, numerous studies reveal positive effect of β-glucans and its derivatives on health, particularly in the field of immunology: they improve wound healing and show antioxidant, antiviral, antibacterial, anti-inflammatory and DNA-protecting activity [25][26][27][28].…”

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confidence: 99%

Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair

et al. 2013

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Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair IntroductionHydroxyapatite (HAp), especially in a porous form, is appreciated as a bone filler due to its biocompatibility, bioactivity, osteoconductivity, minimal risk of appearance of allergic reactions, lack of carcinogenic properties and lack of sensitivity to sterilization processes [1][2][3]. There are numerous commercially available bone graft materials based on biologic and synthetic HAp, including ProOsteon ® (Interpore Cross International, USA), Endobon (BIOMET Orthopaedics, Switzerland), Cerapatite (Ceraver Osteal, France), Synatite (SBM, France) and others. HAp may serve not only as a bone filler but also as a carrier of active substances: antibiotics, chemiotherapeutics, growth factors, etc. [4][5][6][7][8][9]; it can also be used in composites, as a factor increasing their cytocompatibility, bioactivity, osteoconductivity, adhesion of coatings and compression modulus [10][11][12][13][14]. On the other hand, HAp application is often limited due to its relatively poor resorption and slow replacement by the host bone after implantation, substantially high Young modulus, and low fracture toughness [15,16], although these properties may be improved by addition of elasticity-increasing polymers. It is considered that polymer-ceramic composites reveal superior properties (at least in some aspects) over polymer and ceramic alone [17]. However, most polymers used for bone filler fabrication meet only some of the criteria for implantable materials.Bone replacing material such as ceramics or crushed bone offers an insufficient surgical handiness, especially when the orthopedic surgeon has to handle granules (in case of defects in maxillary bone) or scaffolds (rigid and non-adaptable to the implantation site). Some commercially available biomaterials contain the artificial or natural polymers serving as plasticizing agents and thus significantly reduce this inconvenience. Among them, EasyGraft TM (Degradable Solutions SA, Switzerland), Plexur M and P (Osteotech, USA) and Cerapatite-Collagen (Ceraver Osteal, France) can be listed. EasyGraft TM contains PLGA-coated β-TCP granules which hardens into a compact mass via partial and temporary PLGA dissolution by organic solvent; Plexur M and P are composed of cortical bone and resorbable artificial polymer; Cerapatite-Collagen, made from HAp granules and naturally-derived collagen fibers, becomes elastic after hydration with blood or saline. Bone or ceramic granules and powders may also be turned into a paste using collagen gels (e.g., Tecnoss ® Gel O; Tecnoss, Italy) or fibrin glue [18,19]. However, the natural polymeric compounds used in commercially available composites (collagen, fibrin glue) originate from animal sources; this can be considered as a limiting factor because of the increased risk of transmissible contamination (e.g. viruses) and undesirable immune responses. Thus, the necessity of careful purification of these animal polymers exacts the high price of fin...

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Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair

et al. 2013

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“…The gels are prepared by mixing curdlan in drug solutions at 5-10% curdlan concentration, adding the suspension to a glass test tube, heating the test tube in water bath at the desired temperature for 10 minutes and then unmolding the gel. The experiments conducted in [32] have demonstrated that a high-set gel can lower the rate of drug release. The curdlan based gels have been able to provide a sustained release of drugs for compared to commercially available formulations.…”

Section: Encapsulation Within Gelsmentioning

confidence: 99%

“…The curdlan based gels have been able to provide a sustained release of drugs for compared to commercially available formulations. These gels can be used as drug delivery suppositories for rectal administration, which bypasses hepatic first pass clearance [32].…”

Section: Encapsulation Within Gelsmentioning

confidence: 99%

1,3-Beta-Glucans: Drug Delivery and Pharmacology

Verma¹,

Gu²

2012

The Complex World of Polysaccharides

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“…Drug release increases inversely with the melting temperatures of suppositories [17,166]. Lecithin (curdlan) hardens the suppository, which delays suppository melt and prolongs drug release [80]. Large drug particle sizes delay absorption [29,42,147,184], though this has been disputed [102].…”

Section: Pharmaceutical Characteristicsmentioning

confidence: 99%

Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions

Davis¹,

Walsh²,

LeGrand

et al. 2002

Support Care Cancer

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Rectally administered medications are essential in palliative medicine, particularly in the last days of life. They are underutilized. The pharmacology of rectally administered medications relates not only to the medication but also to the suppository base, additives, drug ionization, p K(a), absorptive surface of the rectum, and rectal health. The pharmacokinetics may differ from those of orally administered medications owing to reduced hepatic first-pass clearance. In this review the pharmacology of rectally administered palliative medications is reviewed and the use of individual drugs is outlined.

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Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro.

Cited by 49 publications

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Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair

Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair

1,3-Beta-Glucans: Drug Delivery and Pharmacology

Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions

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