Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances

Hussain, Arif; Kumar, Ajay; Uttam, Vivek; Sharma, Uttam; Sak, Katrin; Saini, Reena V.; Saini, Adesh K.; Haque, Shafiul; Tuli, Hardeep Singh; Jain, Aklank; Sethi, Gautam

doi:10.1016/j.envres.2023.116476

Cited by 12 publications

(4 citation statements)

References 147 publications

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“…A suitable approach that could overcome those problems is using nanocarriers that, targeting inflammation, allow the release of the drug locally, reducing side effects. There are multiple investigations where not only ‘classical synthetic drugs’ but “natural products” have been formulated using nanotechnology to treat different conditions such as cancer, cardiovascular diseases, or inflammation ( Hesari et al, 2021 ; An et al, 2023 ; Hussain et al, 2023 ; Tomou et al, 2023 ; Zandieh et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation

Alsharif,

Hante,

Govoni

et al. 2023

Front. Pharmacol.

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Introduction:Capparis cartilaginea Decne. (CC) originates from the dry regions of Asia and the Mediterranean basin. In traditional medicine, tea of CC leaves is commonly used to treat inflammatory conditions such as rheumatism, arthritis, and gout. Due to the limited studies on the phytochemistry and biological activity of CC compared to other members of the Capparaceae family, this work aims to: 1) Identify the chemical composition of CC extract and 2) Investigate the potential anti-inflammatory effect of CC extract, tea and the isolated compounds.Methods: To guarantee aim 1, high-speed countercurrent chromatography (HSCC) method; Nuclear Magnetic Resonance (NMR) and High-Performance Liquid Chromatography coupled to Electrospray Ionisation and Quadrupole Time-of-Flight Mass Spectrometry (HPLC-ESIQTOF-MS/MS) were employed for this purpose. To guarantee aim 2, we studied the effect of the isolated flavonoids on matrix metalloproteinases (MMPs) −9 and −2 in murine macrophages. Molecular docking was initially performed to assess the binding affinity of the isolated flavonoids to the active site of MMP-9.Results and discussion:In silico model was a powerful tool to predict the compounds that could strongly bind and inhibit MMPs. CC extract and tea have shown to possess a significant antioxidant and anti-inflammatory effect, which can partially explain their traditional medicinal use.

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Section: Discussionmentioning

confidence: 99%

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation

Alsharif,

Hante,

Govoni

et al. 2023

Front. Pharmacol.

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“…92 The lipid membrane of liposomes, comprised of cholesterol, dihexyl phosphate, and egg yolk phosphatidylcholine, makes curcumin soluble. 93 The positively charged nanoliposomes are produced using cationic polyethyleneimine (PEI) and PEG to transport curcumin. This nanoformulation showed 20-fold higher cytotoxicity than curcumin alone in various cell lines, such as cervical carcinoma, human hepatocellular carcinoma, lung carcinoma, and colorectal carcinoma.…”

Section: Liposomementioning

confidence: 99%

“…Recent improvements in liposome formulations have shown reduced toxicity and enhanced the effectiveness of treatment for drug‐resistant tumors 92 . The lipid membrane of liposomes, comprised of cholesterol, dihexyl phosphate, and egg yolk phosphatidylcholine, makes curcumin soluble 93 . The positively charged nanoliposomes are produced using cationic polyethyleneimine (PEI) and PEG to transport curcumin.…”

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

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“…Currently, a common bottleneck problem in the research and application of photosensitive drugs is their weak photostability, which is affected by special wavelength light to produce photodynamic effects and lead to photodegradation, thereby weakening the photodynamic effect of photosensitive drugs or shortening their use cycle. 27–29 Although curcumin has been proven to have good anti-inflammatory, antioxidant, reducing blood sugar levels, lipid-lowering and autoimmune effects, there are still bottlenecks in its application, 30,31 especially the photostability of curcumin, which leads to low bioavailability and seriously restricts the promotion and application of curcumin drug molecules. 32,33 It is urgent to explore a more effective and suitable delivery method for curcumin to improve the effectiveness of the agent.…”

Section: Introductionmentioning

confidence: 99%

Photostabilities and anti-tumor effects of curcumin and curcumin-loaded polydopamine nanoparticles

Yan,

Liao,

Xiao

et al. 2024

RSC Adv.

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Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances

Cited by 12 publications

References 147 publications

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Photostabilities and anti-tumor effects of curcumin and curcumin-loaded polydopamine nanoparticles

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