Application of computers in chemical analysis: amino-acid analysis and sequence determination

Abstract

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Use of a Small Dedicated Computer with a High-Resolution Liquid Chromatograph

“…The number of verifications necessary to recognize the start of a peak, as well as the value of p, depend upon the intensity of the background noise. Although this method differs slightly from other peak-find schemes which have been reported [11,12], our experience has shown it to be quite effective in detecting small, gently sloping chromatographic peaks. The strength of this method lies in the fact that if noise is superimposed on a peak beginning, it is possible that Thus, to detect any given peak, the value of p used in a test which examines successive points must be smaller than that used in the test just described.…”