Application of computational tools for the designing of Oleuropein loaded nanostructured lipid carrier for brain targeting through nasal route

Palagati, Sucharitha; Satyanarayana, Srinath; Kesavan, Bhaskar Reddy

doi:10.1007/s40199-019-00304-0

Cited by 15 publications

(14 citation statements)

References 26 publications

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“…The model F values of responses, 5.04 and 2.68 indicates models are significant. 10,11 P values of both responses were found to be within 0.05 ranges which also imply models are significant. 12,13 Based on the experimental design, the factor combination resulted in different particle size.…”

Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 69%

“…Optimization of micro emulsion formulation was explored by applying response surface methodology and experimental design BBD (Box Behnken Design) using 3 level factorial designs. [10][11][12] Polynomial model was constructed for optimization of Aripiprazole keeping four independent and two dependent variables [ Table 2 which will surely helpful in stable micro emulsion development. [10][11][12][13][14] Pharmaceutical evaluation of Micro emulsion Optical clarity (Percentage transmittance): Percentage transmittance of each formulation was measured at 650 nm using UV-spectrophotometer against distilled water as blank.…”

Section: Optimization Of Micro Emulsion Formulationmentioning

confidence: 99%

“…diagram of 1:2 ratio of surfactant and co-surfactant showed stable micro emulsion region and hence same ratio used further. [9][10] Second-order quadratic polynomial equation and contour plots are constructed by using multiple regression analysis. Microemulsion system optimized using Design space (overlay plot) with softwaresuggested levels of independent variables that could be transformed to desired responses.…”

Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 99%

“…Microemulsion system optimized using Design space (overlay plot) with softwaresuggested levels of independent variables that could be transformed to desired responses. [10][11][12] From response model equations (1,2) it is observed that, variables X1, Oleic acid have negative effect on Particle size while variable X4, distilled water shows negative effect on drug content. Particle size of Aripiprazole is inversely proportional to drug concentration in oleic acid while drug content percentage is inversely proportional to amount of distilled water in micro emulsion.…”

Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 99%

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Quality by Design (QbD) Approach for Optimization and Characterization of Micro emulsion based Nasal formulation of Antipsychotic/Antischizophrenic Drug-Aripiprazole

Deore¹,

Baviskar²,

Kide³

et al. 2020

IJPI

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Introduction: Present study is focused to develop micro emulsion based nasal formulation of poorly water soluble antipsychotic/anti-schizophrenic drug Aripiprazole. Materials and Methods: Different surfactants and co surfactants are screened by implementing pseudo ternary phase diagram. Effect of concentrations of four independent variables-oil (X1), Surfactant (X2), co-surfactant (X3) and water (X4) on two dependent variablesparticle size (Y1) and drug content (Y2) is studied from surface response plots obtained by application of Box Behnken Design Experiment. QTPP and CQA mediated risk assessment applied to ensure desirable quality, safety and efficacy of developed microemulsion. Developed microemulsion evaluated for appearance, particle size, viscosity, drug content, pH, conductivity, drug release, zeta potential, polydispersity index, nasal toxicity and stability. Results: DoE based QBD approach lead development of suitable optimized batch of Aripiprazole micro emulsion with particle size 95.2 nm, viscosity 120 cp, pH 6.0, 90%, drug content and about 87.33% nasal permeability release within 4 hr. Risk assessment helped in identifying identification robust design parameters for rapid development of stable aripiprazole micro emulsion. The critical quality attributes (CQAs) like solubility and compatibility with excipients, dosage form, particle size, turbidity, drug content and drug release have greater impact on the stability and therapeutic performance of micro emulsion of aripiprazole. Conclusion: Aripiprazole containing intranasal micro emulsion is successfully developed by quality by design approach for understanding the critical quality attributes and microemulsion is better alternative over conventional delivery systems.

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Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 69%

Section: Optimization Of Micro Emulsion Formulationmentioning

confidence: 99%

Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 99%

Section: Pharmaceutical Evaluation Of Micro Emulsionmentioning

confidence: 99%

See 2 more Smart Citations

Quality by Design (QbD) Approach for Optimization and Characterization of Micro emulsion based Nasal formulation of Antipsychotic/Antischizophrenic Drug-Aripiprazole

Deore¹,

Baviskar²,

Kide³

et al. 2020

IJPI

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show abstract

“…The optimization was done on the basis of attaining lower particle size, PDI, and higher % EE using overlay plot (graphical) and desirability (numerical) criteria. In order to establish the reliability of the developed model, the check-point analysis was performed by taking two validation batches viz., V1, and V2, whereby the magnitude of error between observed and predicted values was evaluated 17 .…”

Section: Data Optimization and Model Validationmentioning

confidence: 99%

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2020

IJPSR

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The aim of the current investigation was to prepare and investigate the potential of Clobetasol (CP) loaded solid lipid nanoparticles based gel (SLN-gel) for the dermal delivery and to evaluate its anti-psoriatic efficacy by comparing with conventional ointment formulation. This study will provide an insight into the use of nanocarriers, esp. SLNs loaded with CP for the effective treatment of psoriasis. Clobetasol-loaded SLNs were formulated by the emulsification-homogenisation method and were characterized for particle size and polydispersity using DLS technique. The optimized SLNs were loaded into a gel and evaluated for drug release, spreadability. Anti-psoriatic efficacy of the SLNs gel was evaluated in imiquimod (IMQ) induced psoriatic plaque model by comparing with prepared conventional ointment formulation (0.05% w/w CP). Optimized SLNs attains a particle size of 133.3 ± 3.66 nm, polydispersity index (PDI) 0.179 ± 0.081, percentage entrapment efficiency of 78.1 ± 1.11% and Zeta potential of-36.2 ± 0.11 mV. The prepared SLNs gel was then compared with conventional ointment for drug release and efficacy. Topical application of Clobetasol-loaded SLNs gel on IMQ induced psoriatic plaque model reduced the symptoms of psoriasis, which was assessed by both Psoriasis area severity index (PASI) scoring and enzyme-linked immunosorbent assay. There was a significant reduction in disease severity and cytokines like Interleukins-17, 22, 23 and Tumor necrosis factor-a by the developed system in comparison to the negative control. To conclude, CP-loaded SLNs gel enhanced dermal delivery and was efficacious in management of psoriasis when compared to conventional ointment. INTRODUCTION: Psoriasis is a chronic autoimmune skin disorder that was characterized by erythematous lesions with epidermal hyperplasia (acanthosis) and extensive inflammation 1 .

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Tailoring lipid nanoconstructs for the oral delivery of paliperidone: Formulation, optimization and in vitro evaluation

Rehman

Nabi

Baboota

et al. 2021

Chemistry and Physics of Lipids

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Application of computational tools for the designing of Oleuropein loaded nanostructured lipid carrier for brain targeting through nasal route

Cited by 15 publications

References 26 publications

Quality by Design (QbD) Approach for Optimization and Characterization of Micro emulsion based Nasal formulation of Antipsychotic/Antischizophrenic Drug-Aripiprazole

Quality by Design (QbD) Approach for Optimization and Characterization of Micro emulsion based Nasal formulation of Antipsychotic/Antischizophrenic Drug-Aripiprazole

Untitled

Tailoring lipid nanoconstructs for the oral delivery of paliperidone: Formulation, optimization and in vitro evaluation

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