Application of clethodim pesticide water-based formulation prepared by 1-decyl-3-methyl imidazolium bromide aqueous solution

Zhou, Qizhen; He, Xinru; Liu, Fengmao; Li, Yuying; Chen, Chen; Peng, Qiyu

doi:10.1016/j.molliq.2017.09.038

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…Through specifically targeting the structural domain of the plastid ACCase of carboxylase transferase, clethodim inhibits fatty acid biosynthesis and ultimately causes crop death. , To address the crop phytotoxicity induced by clethodim, a novel class of substituted 2-phenyl-2-cyclohexanedione enol ester derivatives was designed and synthesized (Figure a) . The SAR analysis of the target compounds revealed that incorporating a substituent containing a 5-methyl-3-phenylisoxazole structure significantly improved their effectiveness in protecting maize.…”

Section: Structure–activity Relationship (Sar) Of Novel Herbicide Saf...mentioning

confidence: 99%

Herbicide Safeners: From Molecular Structure Design to Safener Activity

Zhao,

Ye,

2024

J. Agric. Food Chem.

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Herbicide safeners, highly effective antidotes, find widespread application in fields for alleviating the phytotoxicity of herbicides to crops. Designing new herbicide safeners remains a notable issue in pesticide research. This review focuses on discussing and summarizing the structure−activity relationships, molecular structures, physicochemical properties, and molecular docking of herbicide safeners in order to explore how different structures affect the safener activities of target compounds. It also provides insights into the application prospects of computer-aided drug design for designing and synthesizing new safeners in the future.

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Section: Structure–activity Relationship (Sar) Of Novel Herbicide Saf...mentioning

confidence: 99%

Herbicide Safeners: From Molecular Structure Design to Safener Activity

Zhao,

Ye,

2024

J. Agric. Food Chem.

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“…3-Hydroxy-2-phenylcyclohex-2-en-1-one (2a). White solid; yield 79%; mp 150-151 C; 1 3-Benzoyloxy-2-phenyl-2-cyclohexen-1-one 3(S1). White solid; yield 50%; mp 75.7-77.2 C; spectroscopic data consistent with those observed previously.…”

Section: General Procedures For the Preparation Of Substituted 3hydroxmentioning

confidence: 99%

“…27 3-Benzoyloxy-2-phenyl-5-methyl-2-cyclohexen-1-one 3(S2). White solid; yield 56%; mp 80.2-81.0 C; 1…”

Section: General Procedures For the Preparation Of Substituted 3hydroxmentioning

confidence: 99%

“…Clethodim, an acetyl CoA carboxylase (ACCase) inhibitor that belongs to the chemical family of cyclohexenone herbicides, specically targets the carboxylase-transferase (CT) domain of the plastidic ACCase, which inhibits fatty acid biosynthesis and ultimately causes crop death. 1,2 Cyclohexenone herbicides are toxic to non-target organisms that also contain this enzyme. 3,4 Clethodim has been shown to cause albinism in canola via the inhibition of fatty acid biosynthesis, which not only causes dramatic crop yield losses but also die-off.…”

Section: Introductionmentioning

confidence: 99%

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Design, microwave-assisted synthesis, bioactivity and SAR of novel substituted 2-phenyl-2-cyclohexanedione enol ester derivatives

Zhai

et al. 2018

RSC Adv.

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“…Kurkal-Siebert applied for patents on new formulations composed of active pesticide ingredients, ILs, and oils in 2013; Marguerre et al applied for patents on water-based pesticide formulations involving ILs. Zhou et al tested the solubilization effect of [C 10 mim][Br] on clethodim, and the results showed that the solubility of clethodim in the 30 wt % IL aqueous solution was enhanced by 229 times compared with pure water, and the 5 g/L clethodim IL aqueous solution has similar control effects as the 120 g/L clethodim EC on Poa pratensis. Recently, Kaczmarek et al designed choline-based ILs as adjuvants in pesticide formulations; they found that ILs have better biocompatibility and could improve the water solubility of the iodosulfuron methyl sodium.…”

Section: Introductionmentioning

confidence: 99%

Amino Acid Ionic Liquids as a Potential Adjuvant for Fungicide Formulations: COSMO-RS Prediction and Dissolution Mechanism Elucidation

Wang

Qiao

et al. 2022

ACS Sustainable Chem. Eng.

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Screening green solvents to improve the solubility of insoluble pesticides in water is a significant development direction for pesticide formulations in the future. Amino acid ionic liquids (AAILs) have strong dissolution properties and are widely used in dissolution. In this work, the conductor-like screening model for real solvents (COSMO-RS) as a solvent screening tool was used to screen AAILs with good solubility for two insoluble fungicides (fludioxonil and cyprodinil) and the physicochemical properties (viscosity, density, and CMC) of AAILs were characterized. The results showed that the selected AAILs had good solubility effects on fungicides, wherein the solubility of fludioxonil and cyprodinil in 1-ethyl-1-methyl-pyrrolidinium glycinate ([Empy][Gly]) was 115.78 and 67.17 g/L, respectively. The mechanism of the AAIL dissolving the fungicide was explored by theoretical calculation and IR characterization, indicating that the hydrogen bond interaction was the main driving force for AAILs to dissolve fungicides. The solubilization effects of AAILs in different systems were explored, and the results showed that the solubilization effect in aqueous solution was positively correlated with the content of AAILs, which was not only related to the interaction between fungicides and AAILs, but also the formation of micelles as an essential factor. Moreover, the impact of the biosurfactant rhamnolipid (Rha) and AAILs on the solubilization effect was explored, and most AAILs demonstrated a synergistic solubilization effect after adding Rha, which was expected. Finally, the inhibitory effects of organic solvent adjuvant methanol and eight AAILs on wheat growth were measured. Three [Empy] ILs showed less inhibitory effects on wheat than methanol under the same concentration. The research results indicated that AAILs had a promising research prospect as cosolvents in pesticide formulations.

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Application of clethodim pesticide water-based formulation prepared by 1-decyl-3-methyl imidazolium bromide aqueous solution

Cited by 8 publications

References 41 publications

Herbicide Safeners: From Molecular Structure Design to Safener Activity

Herbicide Safeners: From Molecular Structure Design to Safener Activity

Design, microwave-assisted synthesis, bioactivity and SAR of novel substituted 2-phenyl-2-cyclohexanedione enol ester derivatives

Amino Acid Ionic Liquids as a Potential Adjuvant for Fungicide Formulations: COSMO-RS Prediction and Dissolution Mechanism Elucidation

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