Application of Chlorogenic acid as a substitute for antibiotics in Multidrug-resistant Escherichia coli-induced mastitis

Feng, Shiyuan; Zhang, Yihao; Fu, Shaodong; Li, Zhi; Zhang, Jinqiu; Xu, Yanyan; Han, Xiangan; Miao, Jinfeng

doi:10.1016/j.intimp.2022.109536

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…Consistently, CHA treatment decreased levels of IFN-γ and TNF-α and increased the expression of occludin in jejunum and colon, thus decreasing intestinal permeability in LPS-stimulated rats [206]. More importantly, CHA also served as an antibiotic alternative to kill E. coli by directly targeting bacterial cell walls and membrane [207] or inducing apoptosis in E. coli via depletion of intracellular ROS [208], even though nearly no studies have been conducted regarding the protective roles of CHA against E. colior C. rodentium-induced enterocolitis. In contrast to this, CHA was found to induce the accumulation of ROS in HT-29 and SW480 cells, thus playing a critical role in CRC [209].…”

Section: Interventional Options Of Polyphenols In Inflammation-relate...mentioning

confidence: 78%

New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

Zhang

Deng

et al. 2023

IJMS

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The intestine is critically crucial for nutrient absorption and host defense against exogenous stimuli. Inflammation-related intestinal diseases, including enteritis, inflammatory bowel disease (IBD), and colorectal cancer (CRC), are heavy burdens for human beings due to their high incidence and devastating clinical symptoms. Current studies have confirmed that inflammatory responses, along with oxidative stress and dysbiosis as critical pathogenesis, are involved in most intestinal diseases. Polyphenols are secondary metabolites derived from plants, which possess convincible anti-oxidative and anti-inflammatory properties, as well as regulation of intestinal microbiome, indicating the potential applications in enterocolitis and CRC. Actually, accumulating studies based on the biological functions of polyphenols have been performed to investigate the functional roles and underlying mechanisms over the last few decades. Based on the mounting evidence of literature, the objective of this review is to outline the current research progress regarding the category, biological functions, and metabolism of polyphenols within the intestine, as well as applications for the prevention and treatment of intestinal diseases, which might provide ever-expanding new insights for the utilization of natural polyphenols.

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Section: Interventional Options Of Polyphenols In Inflammation-relate...mentioning

confidence: 78%

New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

Zhang

Deng

et al. 2023

IJMS

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“…The ability of chlorogenic acid and cinnamaldehyde to suppress drug resistance development in cancer cells and beyond has been indicated by previous investigations [12,109,[148][149][150][151][152]. Toumia et al [153] reported on the ability of CGA-containing plant extract, as an adjuvant, to effectively suppress MDR in cancer cells by downregulating the expression of Pglycoprotein [153].…”

Section: Multidrug Resistance In Breast Cancer Cells: the Potential I...mentioning

confidence: 98%

Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde

Olayiwola,

Gollahon

2024

Pharmaceuticals

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Globally, breast cancer is not only the most frequently diagnosed cancer but also the leading cause of cancer death in women. Depending on breast cancer histotype, conventional breast cancer treatment options vary greatly in efficacy and accompanying side effects. Thus, there is a need for more effective and safer strategies that impact breast cancer at all stages. Plant-based natural products are easily available, with them proving effective and inexpensive. Two such phytochemicals are chlorogenic acid and cinnamaldehyde. Studies have shown their efficacy against different molecular subtypes of breast cancers in vitro and in vivo. In this review, we discuss their current status in anticancer research with specific emphasis on chlorogenic acid and cinnamaldehyde. We describe their multiple mechanisms of action in destroying breast cancer cells, their potential uses, and the need for translational applications. We also include future directions for investigations to progress chlorogenic acid and cinnamaldehyde research from bench to bedside.

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“…4-O-caffeolyqunic, neochlorogenic, and chlorogenic acids were identified as the most potent anti-inflammatory constituents of E. angustifolium extract [24]. Chlorogenic acid is an effective antimicrobial against both Gram-positive and Gramnegative bacteria [138][139][140]. The antimicrobial mechanism of activity of chlorogenic acid is explained by disruption of intracellular and outer membranes and consequently cell metabolism [141,142].…”

Section: Active Compounds Of E Angustifolium Extracts and Mechanisms ...mentioning

confidence: 99%

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

Dreger,

Adamczak,

Foksowicz-Flaczyk

2023

Pharmaceuticals

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The aim of this work was to provide an overview of available information on the antibacterial and antifungal properties of Epilobium angustifolium extracts. A literature search of Scopus, PubMed/Medline, and Google Scholar for peer-reviewed articles published between January 2000 and June 2023 was undertaken. A total of 23 studies were eligible for inclusion in this review. Significant variation of antimicrobial activity depending on the tested species and strains, type of extract solvent, or plant organs utilized for the extract preparation was found. E. angustifolium extracts were active against both Gram-positive and Gram-negative bacteria and showed antimycotic effects against the fungi of Microsporum canis and Trichophyton tonsurans and the dermatophytes Arthroderma spp. Greater susceptibility of Gram-positive than Gram-negative bacteria to fireweed extracts was found. A strong antibacterial effect was recorded for Staphylococcus aureus, Bacillus cereus, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii including multi-drug resistant strains. E. angustifolium extract might find practical application as an antimicrobial in wound healing, components of cosmetic products for human and animals, or as food preservatives.

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Application of Chlorogenic acid as a substitute for antibiotics in Multidrug-resistant Escherichia coli-induced mastitis

Cited by 8 publications

References 26 publications

New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde

Antibacterial and Antimycotic Activity of Epilobium angustifolium L. Extracts: A Review

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