Application of Chitosan and Its Derivatives in Transdermal Drug Delivery

Panonnummal, Rajitha; Kumar, Vrinda S.; Jayakumar, R.; Sabitha, M.

doi:10.1007/12_2021_102

Cited by 3 publications

(2 citation statements)

References 110 publications

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“…Administration of drugs via the skin, smearing, and spraying is known as transdermal drug delivery (Panonnummal et al, 2021). In this method, drugs enter into the body through the cuticle and enter into the hemolymph via passive diffusion.…”

Section: Absorption Distribution and Metabolism Of Drugsmentioning

confidence: 99%

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Mishra¹,

PANDA²,

Barik³

et al. 2023

Biocell

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Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a delay in developmental time, defective growth, structural abnormality of many organs, including sensory organs, behavioral abnormalities, or death in the fetus stage. Numerous model organisms are employed to assess the effect of neurotoxicants. The current review summarizes several methods used to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster.

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Section: Absorption Distribution and Metabolism Of Drugsmentioning

confidence: 99%

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Mishra¹,

PANDA²,

Barik³

et al. 2023

Biocell

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“…Chitosan is a natural cationic linear polysaccharide derived from chitin via a deacetylation reaction in an alkaline solution and composed of randomly distributed β-(1 → 4)-linked d -glucosamine and N -acetyl- d -glucosamine [ 27 ]. Chitosan has been used in topical and transdermal delivery systems due to its non-toxicity, biocompatibility, and biodegradability [ 28 ], as well as its various bioactivities beneficial to the skin, including antioxidant [ 29 ], antibacterial [ 30 ], antifungal [ 31 ], anti-proinflammatory cytokines [ 32 ], and accelerating dermal regeneration [ 33 ]. Furthermore, chitosan could enhance permeation across the skin by interacting with negatively charged cells in the stratum corneum layer, which may alter the secondary structure of keratin and widen the tight junctions to create a looser skin structure, ultimately leading to enhanced transdermal permeation of active compounds [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Alginate Nanoparticles of Protein Hydrolysate from Acheta domesticus with Enhanced Stability for Skin Delivery

Yeerong,

Chantawannakul,

Anuchapreeda

et al. 2024

Pharmaceutics

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This study aimed to develop chitosan alginate nanoparticles (CANPs) for enhanced stability for dermal delivery of protein hydrolysate from Acheta domesticus (PH). CANPs, developed using ionotropic pre-gelation followed by the polyelectrolyte complex technique, were characterized for particle size, polydispersity index (PDI), and zeta potential. After the incorporation of PH into CANPs, a comprehensive assessment included encapsulation efficiency, loading capacity, morphology, chemical analyses, physical and chemical stability, irritation potential, release profile, skin permeation, and skin retention. The most optimal CANPs, comprising 0.6 mg/mL sodium alginate, 1.8 mg/mL calcium chloride, and 0.1 mg/mL chitosan, exhibited the smallest particle size (309 ± 0 nm), the narrowest PDI (0.39 ± 0.01), and pronounced negative zeta potential (−26.0 ± 0.9 mV), along with an encapsulation efficiency of 56 ± 2%, loading capacity of 2.4 ± 0.1%, release of 40 ± 2% after 48 h, and the highest skin retention of 12 ± 1%. The CANPs induced no irritation and effectively enhanced the stability of PH from 44 ± 5% of PH remaining in a solution to 74 ± 4% after three-month storage. Therefore, the findings revealed the considerable potential of CANPs in improving PH stability and skin delivery, with promising applications in cosmetics and related fields.

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A Sustainable Solution to Skin Diseases: Ecofriendly Transdermal Patches

et al. 2023

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Skin is the largest epithelial surface of the human body, with a surface area of 2 m2 for the average adult human. Being an external organ, it is susceptible to more than 3000 potential skin diseases, including injury, inflammation, microbial and viral infections, and skin cancer. Due to its nature, it offers a large accessible site for administrating several medications against these diseases. The dermal and transdermal delivery of such medications are often ensured by utilizing dermal/transdermal patches or microneedles made of biocompatible and biodegradable materials. These tools provide controlled delivery of drugs to the site of action in a rapid and therapeutically effective manner with enhanced diffusivity and minimal side effects. Regrettably, they are usually fabricated using synthetic materials with possible harmful environmental effects. Manufacturing such tools using green synthesis routes and raw materials is hence essential for both ecological and economic sustainability. In this review, natural materials including chitosan/chitin, alginate, keratin, gelatin, cellulose, hyaluronic acid, pectin, and collagen utilized in designing ecofriendly patches will be explored. Their implementation in wound healing, skin cancer, inflammations, and infections will be discussed, and the significance of these studies will be evaluated with future perspectives.

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Application of Chitosan and Its Derivatives in Transdermal Drug Delivery

Cited by 3 publications

References 110 publications

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Chitosan Alginate Nanoparticles of Protein Hydrolysate from Acheta domesticus with Enhanced Stability for Skin Delivery

A Sustainable Solution to Skin Diseases: Ecofriendly Transdermal Patches

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