Application of chitosan and chitosan derivatives as biomaterials

Choi, Changyong; Nam, Joung-Pyo; Nah, Jae‐Woon

doi:10.1016/j.jiec.2015.10.028

Cited by 231 publications

(82 citation statements)

References 161 publications

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“…Chitosan (Cs) is a basic polysaccharide found in nature with good biocompatibility and biodegradability [9]. It possesses various bioactivities such as anti-inflammatory, antibacterial, antifungal, muco-adhesive, and antitumor effects [10–11].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang¹,

Wu²,

Li³

et al. 2016

Beilstein J. Nanotechnol.

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In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs) were prepared by convenient ionic gelation techniques between chitosan (Cs) and tripolyphosphate (TPP). The preparation conditions, including Cs concentration, TPP concentration, Cs/MIF mass ratio, and pH value of the TPP solution, were optimized to gain better encapsulation efficiency (EE) and drug loading capacity (DL). MCNs prepared with the optimum conditions resulted in spherical particles with an average size of 200 nm. FTIR and XRD spectra verified that MIF was successfully encapsulated in CNs. The EE and DL of MCNs determined by HPLC were 86.6% and 43.3%, respectively. The in vitro release kinetics demonstrated that MIF was released from CNs in a sustained-release manner. Compared with free MIF, MCNs demonstrated increased anticancer activity in several cancer cell lines. Pharmacokinetic studies in male rats that were orally administered MCNs showed a 3.2-fold increase in the area under the curve from 0 to 24 h compared with free MIF. These results demonstrated that MCNs could be developed as a potential delivery system for MIF to improve its anticancer activity and bioavailability.

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Section: Introductionmentioning

confidence: 99%

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Zhang¹,

Wu²,

Li³

et al. 2016

Beilstein J. Nanotechnol.

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“…Chitin was discovered in 1811 by Braconnot and chitosan, in 1859, by Rouget [17]. Chitin is made of N-acetyl-D-glucosamine monomer units linked with β(1,4) glycosidic linkage, whereas chitosan is the deacetylated form of chitin [18]. In addition, chitosan presents a rigid crystalline structure due to interand intramolecular hydrogen bonds as a result of the amine and hydroxyl groups [18].…”

Section: Chitin and Chitosan Overviewmentioning

confidence: 99%

Biodegradable Chitosan Matrix Composite Reinforced with Titanium Dioxide for Biocidal Applications

Calero¹,

Berríos²,

Suárez³

2019

Renewable and Sustainable Composites

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Access to drinkable water is increasingly difficult in developing nations. According to the World Health Organization, more than 1.2 billion people lack access to this resource. The scientific community has risen to the challenge by developing innovating methods to purify water. In this context, a chitosan/titanium dioxide biocomposite represents an appealing, economically viable solution to remove oils, heavy metals, and pathogen colonies from contaminated waters. The present chapter reports the study of a chitosan film matrix impregnated with nanoparticles, which was capable of expressing antibacterial properties when exposed to UV light. Several techniques allowed characterizing the biocomposite uniformity, corroborating the crystal structure and assessing the bonding type of this biocomposite mixture. Antibacterial tests with Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) were completed via growth curve analysis and the Kirby-Bauer technique. The results of this encompassing study revealed that bacterial growth was reduced by more than 50%. Optical microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction helped to characterize this biocomposite film. This chapter discusses how a novel and biodegradable film represents a better antibacterial material that is able to eliminate pathogens cost-effectively.

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“…It is important to notice that both chitin and chitosan oligomers are molecules that possess bioactive properties (against tumors, bacteria, and fungi) that makes them suitable for the biomedical and pharmaceutical industry. In particular, since chitosan is a cationic biopolymer, it is widely studied as a carrier for the delivery of genetic materials (DNA, RNA) forming complexes by electrostatic interaction [84]. The chemistry of chitosan is strongly due to the reactivity of its amino groups, which can be used as reactive sites for the functionalization of the biopolymers with hydrophilic, hydrophobic, cationic, anionic, or specific selective moieties, thus enhancing the possibility of its use.…”

Section: Chitin: a European Opportunitymentioning

confidence: 99%

Aquatic-Derived Biomaterials for a Sustainable Future: A European Opportunity

Nisticò

2017

Resources

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Abstract:The valorization of aquatic-derived biowastes as possible feedstock for the production of value-added chemicals and materials is proposed here as a sustainable alternative compared to the exploitation of the more conventional (fossil) resources. In this context, the comprehension of the opportunity related to the valorization of the shellfish industry biowaste for the production of useful materials, especially focusing on chitin and its derived byproducts, is investigated. The large amount of waste produced each year by the shellfish processing industry seems to be an appealing opportunity for the European market to produce valuable products from underutilized waste. In order to highlight this important market-opportunity, the actual European situation concerning the shellfish volume of production is presented. The industrial processes necessary for the recovery of chitin, chitosan, and their derivatives are largely described, together with a wide description of their peculiar (and interesting) physicochemical properties. Even if nowadays the scientific literature suggests that this class of biopolymers is very appealing, further research is still necessary for overcoming some criticisms still present in the extraction and valorization of such substrates. However, the principles of both circular economy and green chemistry encourage the reduction of such biowastes and their exploitation as an alternative resource for a global sustainable future.

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Application of chitosan and chitosan derivatives as biomaterials

Cited by 231 publications

References 161 publications

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

Biodegradable Chitosan Matrix Composite Reinforced with Titanium Dioxide for Biocidal Applications

Aquatic-Derived Biomaterials for a Sustainable Future: A European Opportunity

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