Application of Chemometrics in Biosensing: A Brief Review

Abstract

The field of biosensing is rapidly developing, and the number of novel sensor architectures and different sensing elements is growing fast. One of the most important features of all biosensors is their very high selectivity stemming from the use of bioreceptor recognition elements. The typical calibration of a biosensor requires simple univariate regression to relate a response value with an analyte concentration. Nevertheless, dealing with complex real-world sample matrices may sometimes lead to undesired interference effects from various components. This is where chemometric tools can do a good job in extracting relevant information, improving selectivity, circumventing a non-linearity in a response. This brief review aims to discuss the motivation for the application of chemometric tools in biosensing and provide some examples of such applications from the recent literature.

Enzymes and Their Forms Used in Detection of Organophosphorus Compounds

“…Тем самым объединение в одной биоаналитической системе разных ферментов позволяет достигать таких характеристик самого анализа, которые не доступны при использовании этих компонентов по отдельности. Более того, при этом становится возможным проводить дискриминационный анализ разных соединений, присутствующих одновременно в смеси и в аналите, в том числе с привлечением искусственных нейронных сетей и хемометрики [97].…”

“…Современные запросы стимулируют бурное развитие портативных и, особенно, «мобильных, портативных» биосенсоров, закрепляемых на различных поверхностях и, в том числе, на одежде [109]. И хотя пока очень малое число исследований посвящено именно ферментным биочувствительным элементам в составе таких биосенсоров на ФОС [97], очевидно, что значительный прогресс в данной области можно ожидать в ближайшие годы. Прогресс, достигнутый в области создания аффинных аминокислотных последовательностей [110] в перспективе позволит создавать ферментные биосенсоры на любой поверхности.…”

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