Application of Cationic Poly(lactic‐co‐glycolic acid) Iron Oxide/Chitosan‐Based Nanocomposite for the Determination of Paraoxon

Abstract

The preparation of stable oleic‐acid‐capped iron‐oxide nanoparticles is reported, which were further coated with cationic poly (d,l‐lactic‐co‐glycolic acid) and chitosan in aqueous media by using a nano‐emulsion technique. The prepared composite was used to modify a glassy carbon electrode and the electrochemical behavior and stability of modified electrode were investigated by using cyclic voltammetry. This platform was then utilized to prepare an electrochemical pesticide biosensor based on the inhibition study of the enzyme acetylcholinesterase. Furthermore, the response characteristics show that this fabricated electrode has a shelf life of about 3–4 months and has good adhesion properties along with homogeneous dispersion at the electrode surface. The linear range and detection limit for paraoxon pesticide detection was found to be 9.55–37.1 nM and 8.91 nM, respectively.