Application of cation-modified sulfur nanoparticles as an efficient sorbent for separation and preconcentration of carbamazepine in biological and pharmaceutical samples prior to its determination by high-performance liquid chromatography

Ghoraba, Zahra; Aibaghi, Behzad; Soleymanpour, Ahmad

doi:10.1016/j.jchromb.2017.07.048

Cited by 19 publications

(10 citation statements)

References 41 publications

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“…Therefore, the solid-phase extraction method is considered as an alternative method for the analysis of drugs in the plasma due to its good extraction ability, convenient operation, and consumption of a low amount of organic solvents and it needs a low amount of adsorbent. Compared with earlier reported methods by using different equipments, our method showed high precision, wider linear range, and comparable detection limit (see Table 4) [16,[37][38][39][40][41][42][43][44]. These results demonstrate the advantages of the current method over the available methods, and in addition to this, there were no studies that reported on the simultaneous extraction of these three antiepileptic drugs using the solid-phase extraction method.…”

Section: Discussionsupporting

confidence: 50%

“…CBZ is a mood-stabilizing and anticonvulsant tricyclic lipophilic drug. This drug is the first one to treat epilepsy for psychomotor and partial onset of seizures and is also used for variability of indications, including schizophrenia, attention-deficit hyperactivity disorder (ADHD), paroxysmal dangerous pain disorder, phantom limb disease, and post-traumatic stress syndrome [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Simple and efficient method for the quantification of antiepileptic drugs in human plasma by using magnetic graphene oxide-β-cyclodextrin composite as a sorbent

et al. 2021

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Background In recent days, solid-phase extraction methods are widely utilized for the extraction of drug molecules from plasma samples due to their easy operating procedures and low matrix effect. The trace-level solid-phase extraction of three structurally related antiepileptic drugs brivaracetam (BVC), eslicarbazepine acetate (ESL), and carbamazepine (CBZ) was investigated by using a magnetic porous material graphene oxide-β-cyclodextrin (MGO-CD). Morphology, magnetic properties, and structure of the synthesized MGO-CD were characterized by using FT-IR, SEM, XRD, and VSM. Results Solid-phase extraction (SPE) methods were used to extract the analytes from human plasma. Different extraction solvents such as acetonitrile (ACN), methanol (MeOH), acetone, chloroform (CHCl3), tertiary butyl diethyl ether (TBDE), and ethyl acetate (EtOAc) with variable polarities were used to extract drug molecules from MGO-CD. The linearity analysis showed good correlation coefficient values (R2) of 0.9989, 0.9995, and 0.9982 for BVC, ESL, and CBZ respectively. The LOD and LOQ ranges were found to be 6.14–28.32 ng mL−1 and 20.45–94.31 ng mL−1 respectively. Conclusion The high accuracy and precision made the developed HPLC method with MGO-CD a suitable alternative for the bioequivalence study of BVC, ESL, and CBZ in human plasma. This developed HPLC-UV method has good efficiency for recoveries and good linearity and is simple to handle. And also, it gave low retention time for the three antiepileptic drugs within 8 min. It provides high efficiency for the extraction of trace-level substances from human plasma.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Simple and efficient method for the quantification of antiepileptic drugs in human plasma by using magnetic graphene oxide-β-cyclodextrin composite as a sorbent

et al. 2021

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“…Although effective, the methods by which these materials are synthesized are expensive and, in some cases, not environmentally friendly. Recent research has shown the high efficiency and effectiveness of different nanomaterials in the adsorption/desorption of various pharmaceuticals from different matrices [ 11 , 12 , 13 , 14 , 15 ]. Among these nanomaterials, quaternized chitosan/polystyrene microbeads [ 16 ], magnetic clay nanotubes [ 17 ], cross-linked spherical polycationic [ 18 ], and quaternary ammonium-functionalized halloysite nanotubes [ 19 ] have especially been designed for the recovery of heparin.…”

Section: Introductionmentioning

confidence: 99%

Efficient Heparin Recovery from Porcine Intestinal Mucosa Using Zeolite Imidazolate Framework-8

et al. 2022

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Heparin is one of the most valuable active pharmaceutical ingredients, and it is generally isolated from porcine intestinal mucosa. Traditionally, different types of commercial resins are employed as an adsorbent for heparin uptake; however, using new, less expensive adsorbents has attracted more interest in the past few years to enhance the heparin recovery. Zeolite imidazolate framework-8 (ZIF-8), as a metal–organic framework (MOF) with a high surface area, porosity, and good stability at high temperatures, was selected to examine the heparin recovery. In this research, we demonstrate that ZIF-8 can recover up to ~70% (37 mg g−1) of heparin from porcine intestinal mucosa. A mechanistic study through kinetic and thermodynamic models on the adsorption revealed appropriate surface conditions for the adsorption of heparin molecules. The effect of different variables such as pH and temperature on heparin adsorption was also studied to optimize the recovery. This study is the first to investigate the usage of MOFs for heparin uptake.

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“…Although there are several different medicines commercially available, most of them have similar side effects (mainly in the early stages of administration), and a slow time to start acting on the human brain [5]. Besides these, other medications, such as antiepileptic drugs, can also be used to treat such disorders since they can act as mood stabilizers in some cases [6].…”

Section: Introductionmentioning

confidence: 99%

Multidimensional Liquid Chromatography Employing a Graphene Oxide Capillary Column as the First Dimension: Determination of Antidepressant and Antiepileptic Drugs in Urine

et al. 2020

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Human mental disorders can be currently classified as one of the most relevant health topics. Including in this are depression and anxiety, which can affect us at any stage of life, causing economic and social problems. The treatments involve cognitive psychotherapy, and mainly the oral intake of pharmaceutical antidepressants. Therefore, the development of analytical methods for monitoring the levels of these drugs in biological fluids is critical. Considering the current demand for sensitive and automated analytical methods, the coupling between liquid chromatography and mass spectrometry, combined with suitable sample preparation, becomes a useful way to improve the analytical results even more. Herein we present an automated multidimensional method based on high-performance liquid chromatography-tandem mass spectrometry using a lab-made, graphene-based capillary extraction column connected to a C8 analytical column to determined five pharmaceutical drugs in urine. A method enhancement was performed by considering the chromatographic separation and the variables of the loading phase, loading time, loading flow, and injection volume. Under optimized conditions, the study reports good linearity with R2 > 0.98, and limits of detection in the range of 0.5–20 µg L−1. Afterward, the method was applied to the direct analysis of ten untreated urine samples, reporting traces of citalopram in one of them. The results suggest that the proposed approach could be a promising alternative that provides direct and fully automated analysis of pharmaceutical drugs in complex biological matrices.

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Application of cation-modified sulfur nanoparticles as an efficient sorbent for separation and preconcentration of carbamazepine in biological and pharmaceutical samples prior to its determination by high-performance liquid chromatography

Cited by 19 publications

References 41 publications

Simple and efficient method for the quantification of antiepileptic drugs in human plasma by using magnetic graphene oxide-β-cyclodextrin composite as a sorbent

Simple and efficient method for the quantification of antiepileptic drugs in human plasma by using magnetic graphene oxide-β-cyclodextrin composite as a sorbent

Efficient Heparin Recovery from Porcine Intestinal Mucosa Using Zeolite Imidazolate Framework-8

Multidimensional Liquid Chromatography Employing a Graphene Oxide Capillary Column as the First Dimension: Determination of Antidepressant and Antiepileptic Drugs in Urine

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