Application of Calcium Acetylacetonate to the Polymerization of Glycolide and Copolymerization of Glycolide with ε-Caprolactone and<scp>l</scp>-Lactide

Dobrzyński, P.; Kasperczyk, Janusz; Bero, Maciej

doi:10.1021/ma981969z

Cited by 121 publications

(79 citation statements)

References 21 publications

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“…21 This article presents the results of copolymerization of lactide with glycolide and e-caprolactone initiated by butylmagnesium and magnesium and lithium acetylacetonates carried out in bulk. It has been shown that the copolymers with the amount of glycolidyl units lower than 22% can be obtained via solution polymerization using butyllithium as the initiator.…”

Section: Introductionmentioning

confidence: 99%

Application of the lithium and magnesium initiators for the synthesis of glycolide, lactide, and ϵ‐caprolactone copolymers biocompatible with brain tissue

Dobrzyński

Kasperczyk

Jelonek

et al. 2006

J Biomedical Materials Res

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The subject of this work is new method of the synthesis of biodegradable copolymers compatible with brain tissue. Copolymerization of glycolide with lactide was conducted in solution or in bulk in the presence of LiBu, LiAcac, MgBu(2), Mg(acac)(2) as initiators. In all cases, copolymers with molecular weight of 20000-40000 were obtained, which enables to use them as drug carriers. During the reactions of copolymer chain growth, the intermolecular transesterification occurs, changing the distribution of comonomeric units in copolymer chain. Magnesium initiators showed a lower contribution to transesterification in comparison with lithium and calcium compounds. The copolymerization of glycolide with epsilon-caprolactone using magnesium compounds as initiators was also described. The random glycolide/epsilon-caprolactone copolymer (10/90) obtained with MgBu(2) was used in in vivo study in the forms of microspheres and foils. Complete degradation of microspheres during 6 weeks was observed after the implantation to brain tissue. All implanted copolymers are compatible with brain tissue.

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Section: Introductionmentioning

confidence: 99%

Application of the lithium and magnesium initiators for the synthesis of glycolide, lactide, and ϵ‐caprolactone copolymers biocompatible with brain tissue

Dobrzyński

Kasperczyk

Jelonek

et al. 2006

J Biomedical Materials Res

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“…4 -6 Considerable efforts to develop scaffolds for tissue engineering have been recently attempted using biodegradable and biocompatible polymers such as poly(dl-lactideco-glycolide), poly(l-lactide-co-glycolide), or poly(-CL) (PCL). [7][8][9][10] Principally, the scaffold should be designed by mimicking the structure and biological function of native extracellular matrix (ECM) proteins, which provide mechanical support and regulate cell activities. The polymer morphology, such as the crystallinity and melting point, plays an especially important role in the degradation process.…”

Section: Introductionmentioning

confidence: 99%

Electrospun nanofibers of block copolymer of trimethylene carbonate and ϵ‐caprolactone

Jia

Kim

Gong

et al. 2005

J of Applied Polymer Sci

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ABSTRACT:The electrospinning behavior of a block copolymer of trimethylene carbonate (TMC) and -caprolactone dissolved in N,N-dimethylformamide (DMF) and methylene chloride (MC) was studied. The effects of the blended solvent volume ratio, concentration, voltage, and tip-collector distance (TCD) on the morphology of the electrospun fibers were investigated by scanning electron microscopy. The results indicated that the diameter of the electrospun fibers decreased with a decreasing molar ratio of MC to DMF, but beads formed gradually. With a decreasing concentration of the solution, the fiber diameter decreased; at the same time, beads also appeared and changed from spindlelike to spherical. A higher voltage and larger TCD favored the formation of smaller diameter electrospun fibers. The results of differential scanning calorimetry and X-ray diffraction showed that the crystallinity and melting point of the electrospun fibers decreased when increasing the TMC content in the copolymer. Compared with the corresponding films, the crystallinity and melting point of the electrospun fibers were obviously increased.

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“…This situation has prompted several research groups to explore the usefulness of initiators based on rather non toxic metals, such as Fe [20][21][22], Zn [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39], K [40], Ca, Mg and Bi [4,[40][41][42][43][44][45][46][47][48][49][50][51]. Calcium based catalysts may serve this purpose and are gaining lots of interest.…”

Section: Introductionmentioning

confidence: 99%

MgH2/PEG initiating system for ring opening polymerization of lactone and lactide

2010

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Dihydroxy-terminated poly(ethylene glycol) and MgH 2 form an efficient initiating system for the ring opening polymerization of ε-caprolactone and Llactide. Polycaprolactone-block-polyethylene glycol-block-polycaprolactone and polylactide-block-polyethylene glycol-block-polylactide were synthesized in bulk at 120 °C for 16 h under argon. MgH 2 provided a faster polymerization rate compared with other initiating systems based on non toxic metals used under vacuum. Molecular weight of copolymers varied according to the monomer / ethylene oxide units ratio. The developed procedure led to easy polymerization with better control of the design, molecular weight and polydispersity of the final material. Copolymers were characterized by SEC, DSC,

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Application of Calcium Acetylacetonate to the Polymerization of Glycolide and Copolymerization of Glycolide with ε-Caprolactone andl-Lactide

Cited by 121 publications

References 21 publications

Application of the lithium and magnesium initiators for the synthesis of glycolide, lactide, and ϵ‐caprolactone copolymers biocompatible with brain tissue

Application of the lithium and magnesium initiators for the synthesis of glycolide, lactide, and ϵ‐caprolactone copolymers biocompatible with brain tissue

Electrospun nanofibers of block copolymer of trimethylene carbonate and ϵ‐caprolactone

MgH2/PEG initiating system for ring opening polymerization of lactone and lactide

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